http://purl.uniprot.org/citations/20981447 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/20981447 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/20981447 | http://www.w3.org/2000/01/rdf-schema#comment | "Diffuse panbronchiolitis (DPB) is a rare complex genetic disease affecting East Asians and is strongly associated with the class I human leukocyte antigens (HLA)-B54 in Japanese and HLA-A11 in Koreans. We recently showed that an HLA-associated major susceptibility gene for DPB is probably located within the 200 kb in the class I region 300 kb telomeric of the HLA-B locus on the chromosome 6p21.3. We cloned two novel mucin-like genes designated panbronchiolitis related mucin-like 1 and 2 (PBMUCL1 and PBMUCL2) in the candidate region, which form a mucin-like gene cluster together with two adjacent genes, MUC21 and DPCR1. PBMUCL1 gene expression was remarkably upregulated by polyinosine-polycytidylic acid [poly(I:C)] stimulation in normal human bronchial epithelial cells redifferentiated at the air-liquid interface. We found genetic polymorphisms in PBMUCL1 gene which were associated with DPB: the A-allele of the PBMUCL1 intron 2 single nucleotide polymorphism (SNP) was positively associated and variable numbers of tandem repeats (VNTR) polymorphism in exon 3 (1,890-base pair deletion) was negatively associated. Despite a strong association with HLA-B in the Japanese, the mucin-like gene PBMUCL1 is also one of the candidate genes of DPB susceptibility."xsd:string |
http://purl.uniprot.org/citations/20981447 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00439-010-0906-4"xsd:string |
http://purl.uniprot.org/citations/20981447 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00439-010-0906-4"xsd:string |
http://purl.uniprot.org/citations/20981447 | http://purl.uniprot.org/core/author | "Hijikata M."xsd:string |
http://purl.uniprot.org/citations/20981447 | http://purl.uniprot.org/core/author | "Hijikata M."xsd:string |
http://purl.uniprot.org/citations/20981447 | http://purl.uniprot.org/core/author | "Itoh H."xsd:string |
http://purl.uniprot.org/citations/20981447 | http://purl.uniprot.org/core/author | "Itoh H."xsd:string |
http://purl.uniprot.org/citations/20981447 | http://purl.uniprot.org/core/author | "Tsuchiya T."xsd:string |
http://purl.uniprot.org/citations/20981447 | http://purl.uniprot.org/core/author | "Tsuchiya T."xsd:string |
http://purl.uniprot.org/citations/20981447 | http://purl.uniprot.org/core/author | "Taguchi Y."xsd:string |
http://purl.uniprot.org/citations/20981447 | http://purl.uniprot.org/core/author | "Taguchi Y."xsd:string |
http://purl.uniprot.org/citations/20981447 | http://purl.uniprot.org/core/author | "Tokunaga K."xsd:string |
http://purl.uniprot.org/citations/20981447 | http://purl.uniprot.org/core/author | "Tokunaga K."xsd:string |
http://purl.uniprot.org/citations/20981447 | http://purl.uniprot.org/core/author | "Keicho N."xsd:string |
http://purl.uniprot.org/citations/20981447 | http://purl.uniprot.org/core/author | "Keicho N."xsd:string |
http://purl.uniprot.org/citations/20981447 | http://purl.uniprot.org/core/author | "Matsushita I."xsd:string |
http://purl.uniprot.org/citations/20981447 | http://purl.uniprot.org/core/author | "Matsushita I."xsd:string |
http://purl.uniprot.org/citations/20981447 | http://purl.uniprot.org/core/author | "Homma S."xsd:string |
http://purl.uniprot.org/citations/20981447 | http://purl.uniprot.org/core/author | "Homma S."xsd:string |
http://purl.uniprot.org/citations/20981447 | http://purl.uniprot.org/core/author | "Kudoh S."xsd:string |
http://purl.uniprot.org/citations/20981447 | http://purl.uniprot.org/core/author | "Kudoh S."xsd:string |
http://purl.uniprot.org/citations/20981447 | http://purl.uniprot.org/core/author | "Tanaka G."xsd:string |
http://purl.uniprot.org/citations/20981447 | http://purl.uniprot.org/core/author | "Tanaka G."xsd:string |