| http://purl.uniprot.org/citations/21029969 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21029969 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21029969 | http://www.w3.org/2000/01/rdf-schema#comment | "Although carcinoembryonic antigen-related cell adhesion molecule-1 (CEACAM1) is an activation marker for neutrophils and delays neutrophil apoptosis, the role of CEACAM1 in granulopoiesis and neutrophil-dependent host immune responses has not been investigated. CEACAM1 expression correlated with granulocytic differentiation, and Ceacam1(-/-) mice developed neutrophilia because of loss of the Src-homology-phosphatase-1 (SHP-1)-dependent inhibition of granulocyte colony-stimulating factor receptor (G-CSFR) signal transducer and activator of transcription (Stat3) pathway provided by CEACAM1. Moreover, Ceacam1(-/-) mice were hypersensitive to Listeria Monocytogenes (LM) infection with an accelerated mortality. Reintroduction of CEACAM1 into Ceacam1(-/-) bone marrow restored normal granulopoiesis and host sensitivity to LM infection, while mutation of its immunoreceptor tyrosine-based inhibitory motifs (ITIMs) abrogated this restoration. shRNA-mediated reduction of Stat3 amounts rescued normal granulopoiesis, attenuating host sensitivity to LM infection in Ceacam1(-/-) mice. Thus, CEACAM1 acted as a coinhibitory receptor for G-CSFR regulating granulopoiesis and host innate immune response to bacterial infections."xsd:string |
| http://purl.uniprot.org/citations/21029969 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2010.10.009"xsd:string |
| http://purl.uniprot.org/citations/21029969 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2010.10.009"xsd:string |
| http://purl.uniprot.org/citations/21029969 | http://purl.uniprot.org/core/author | "Pan H."xsd:string |
| http://purl.uniprot.org/citations/21029969 | http://purl.uniprot.org/core/author | "Pan H."xsd:string |
| http://purl.uniprot.org/citations/21029969 | http://purl.uniprot.org/core/author | "Shively J.E."xsd:string |
| http://purl.uniprot.org/citations/21029969 | http://purl.uniprot.org/core/author | "Shively J.E."xsd:string |
| http://purl.uniprot.org/citations/21029969 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21029969 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21029969 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/21029969 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
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| http://purl.uniprot.org/citations/21029969 | http://purl.uniprot.org/core/pages | "620-631"xsd:string |
| http://purl.uniprot.org/citations/21029969 | http://purl.uniprot.org/core/title | "Carcinoembryonic antigen-related cell adhesion molecule-1 regulates granulopoiesis by inhibition of granulocyte colony-stimulating factor receptor."xsd:string |
| http://purl.uniprot.org/citations/21029969 | http://purl.uniprot.org/core/title | "Carcinoembryonic antigen-related cell adhesion molecule-1 regulates granulopoiesis by inhibition of granulocyte colony-stimulating factor receptor."xsd:string |
| http://purl.uniprot.org/citations/21029969 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/21029969 | http://purl.uniprot.org/core/volume | "33"xsd:string |
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| http://purl.uniprot.org/uniprot/P40223 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/21029969 |
| http://purl.uniprot.org/uniprot/P31809 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/21029969 |