| http://purl.uniprot.org/citations/21030553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21030553 | http://www.w3.org/2000/01/rdf-schema#comment | "The genetics of peripheral T-cell lymphomas are poorly understood. The most well-characterized abnormalities are translocations involving ALK, occurring in approximately half of anaplastic large cell lymphomas (ALCLs). To gain insight into the genetics of ALCLs lacking ALK translocations, we combined mate-pair DNA library construction, massively parallel ("Next Generation") sequencing, and a novel bioinformatic algorithm. We identified a balanced translocation disrupting the DUSP22 phosphatase gene on 6p25.3 and adjoining the FRA7H fragile site on 7q32.3 in a systemic ALK-negative ALCL. Using fluorescence in situ hybridization, we demonstrated that the t(6;7)(p25.3;q32.3) was recurrent in ALK-negative ALCLs. Furthermore, t(6;7)(p25.3;q32.3) was associated with down-regulation of DUSP22 and up-regulation of MIR29 microRNAs on 7q32.3. These findings represent the first recurrent translocation reported in ALK-negative ALCL and highlight the utility of massively parallel genomic sequencing to discover novel translocations in lymphoma and other cancers."xsd:string |
| http://purl.uniprot.org/citations/21030553 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2010-08-303305"xsd:string |
| http://purl.uniprot.org/citations/21030553 | http://purl.uniprot.org/core/author | "Smith D.I."xsd:string |
| http://purl.uniprot.org/citations/21030553 | http://purl.uniprot.org/core/author | "Vasmatzis G."xsd:string |
| http://purl.uniprot.org/citations/21030553 | http://purl.uniprot.org/core/author | "Wieben E.D."xsd:string |
| http://purl.uniprot.org/citations/21030553 | http://purl.uniprot.org/core/author | "Eckloff B.W."xsd:string |
| http://purl.uniprot.org/citations/21030553 | http://purl.uniprot.org/core/author | "Dogan A."xsd:string |
| http://purl.uniprot.org/citations/21030553 | http://purl.uniprot.org/core/author | "Johnson S.H."xsd:string |
| http://purl.uniprot.org/citations/21030553 | http://purl.uniprot.org/core/author | "Ansell S.M."xsd:string |
| http://purl.uniprot.org/citations/21030553 | http://purl.uniprot.org/core/author | "Feldman A.L."xsd:string |
| http://purl.uniprot.org/citations/21030553 | http://purl.uniprot.org/core/author | "Law M.E."xsd:string |
| http://purl.uniprot.org/citations/21030553 | http://purl.uniprot.org/core/author | "Porcher J.C."xsd:string |
| http://purl.uniprot.org/citations/21030553 | http://purl.uniprot.org/core/author | "Ozsan N."xsd:string |
| http://purl.uniprot.org/citations/21030553 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21030553 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/21030553 | http://purl.uniprot.org/core/pages | "915-919"xsd:string |
| http://purl.uniprot.org/citations/21030553 | http://purl.uniprot.org/core/title | "Discovery of recurrent t(6;7)(p25.3;q32.3) translocations in ALK-negative anaplastic large cell lymphomas by massively parallel genomic sequencing."xsd:string |
| http://purl.uniprot.org/citations/21030553 | http://purl.uniprot.org/core/volume | "117"xsd:string |
| http://purl.uniprot.org/citations/21030553 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21030553 |
| http://purl.uniprot.org/citations/21030553 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21030553 |
| http://purl.uniprot.org/uniprot/#_A0A384NLC8-mappedCitation-21030553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21030553 |
| http://purl.uniprot.org/uniprot/#_Q9NRW4-mappedCitation-21030553 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21030553 |
| http://purl.uniprot.org/uniprot/A0A384NLC8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21030553 |
| http://purl.uniprot.org/uniprot/Q9NRW4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21030553 |