| http://purl.uniprot.org/citations/21030692 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21030692 | http://www.w3.org/2000/01/rdf-schema#comment | "We recently reported that c-Jun N-terminal kinase (JNK) is associated with adherens junctions and phosphorylates β-catenin at serine 33/37 and threonine 41. Here, we report that inhibition of JNK led to formation of adherens junctions, which was accompanied by dissociation of α-catenin from the β-catenin/E-cadherin complex and increased association of α-catenin with the cytoskeleton. Conversely, activation of JNK increased binding of α-catenin to β-catenin, which was blocked by the JNK inhibitor SP600125 or JNK siRNA. In addition, inhibition of JNK failed to lead to adherens junction formation in cells where α-catenin was absent or knocked down. Conversely, introduction of α-catenin restored the responsiveness of cells to JNK inhibition and led to cell-cell adhesion. Experiments with domain deletion mutants showed that binding of α-catenin to β-catenin was required for transport of adherens junction complexes to the cell surface, while binding to actin was required for translocation to the cell-cell contact sites. Collectively, our results suggest that JNK affects the association of α-catenin with the adherens junction complex and regulates adherens junctions."xsd:string |
| http://purl.uniprot.org/citations/21030692 | http://purl.org/dc/terms/identifier | "doi:10.1096/fj.10-161380"xsd:string |
| http://purl.uniprot.org/citations/21030692 | http://purl.uniprot.org/core/author | "Lee M.H."xsd:string |
| http://purl.uniprot.org/citations/21030692 | http://purl.uniprot.org/core/author | "Andreadis S.T."xsd:string |
| http://purl.uniprot.org/citations/21030692 | http://purl.uniprot.org/core/author | "Koria P."xsd:string |
| http://purl.uniprot.org/citations/21030692 | http://purl.uniprot.org/core/author | "Padmashali R."xsd:string |
| http://purl.uniprot.org/citations/21030692 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21030692 | http://purl.uniprot.org/core/name | "FASEB J"xsd:string |
| http://purl.uniprot.org/citations/21030692 | http://purl.uniprot.org/core/pages | "613-623"xsd:string |
| http://purl.uniprot.org/citations/21030692 | http://purl.uniprot.org/core/title | "JNK regulates binding of alpha-catenin to adherens junctions and cell-cell adhesion."xsd:string |
| http://purl.uniprot.org/citations/21030692 | http://purl.uniprot.org/core/volume | "25"xsd:string |
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