http://purl.uniprot.org/citations/21036735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/21036735 | http://www.w3.org/2000/01/rdf-schema#comment | "AimThe aim of this study was to explore possible differences in the mRNA expression levels of CRIM1, SMAD5, BMP4 and BMP7 in sensitive (S) and multidrug-resistant (R0.5) myeloid leukemia HL60 cells.Materials and methodsHL60S and HL60R0.5 cells were exposed to daunorubicin (DNR) or cytarabine (Ara-C).ResultsBaseline levels of CRIM1 were found to be 15-fold higher in HL60R0.5 than in HL60S. Sixteen hours of exposure to DNR resulted in a 5.6-fold increase in CRIM1 levels in HL60S. Exposure to either DNR or Ara-C resulted in modest increases in CRIM1 levels in HL60R0.5. Similarly, baseline levels of SMAD5 and BMP4 were higher in HL60R0.5 than in HL60S cells. Analysis of the drug SMAD5-resistance marker permeability-glycoprotein (Pgp) revealed that CRIM1 and Pgp exhibit a covariance pattern of expression.ConclusionThis study demonstrated that CRIM1 is expressed at high levels in resistant leukemia cells, indicating that CRIM1 may play a role in drug-resistance."xsd:string |
http://purl.uniprot.org/citations/21036735 | http://purl.uniprot.org/core/author | "Strid H."xsd:string |
http://purl.uniprot.org/citations/21036735 | http://purl.uniprot.org/core/author | "Tidefelt U."xsd:string |
http://purl.uniprot.org/citations/21036735 | http://purl.uniprot.org/core/author | "Uggla B."xsd:string |
http://purl.uniprot.org/citations/21036735 | http://purl.uniprot.org/core/author | "Prenkert M."xsd:string |
http://purl.uniprot.org/citations/21036735 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
http://purl.uniprot.org/citations/21036735 | http://purl.uniprot.org/core/name | "Anticancer Res"xsd:string |
http://purl.uniprot.org/citations/21036735 | http://purl.uniprot.org/core/pages | "4157-4161"xsd:string |
http://purl.uniprot.org/citations/21036735 | http://purl.uniprot.org/core/title | "CRIM1 is expressed at higher levels in drug-resistant than in drug-sensitive myeloid leukemia HL60 cells."xsd:string |
http://purl.uniprot.org/citations/21036735 | http://purl.uniprot.org/core/volume | "30"xsd:string |
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