| http://purl.uniprot.org/citations/21036871 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21036871 | http://www.w3.org/2000/01/rdf-schema#comment | "Ribosome biogenesis requires multiple nuclease activities to process pre-rRNA transcripts into mature rRNA species and eliminate defective products of transcription and processing. We find that in mammalian cells, the 5' exonuclease Xrn2 plays a major role in both maturation of rRNA and degradation of a variety of discarded pre-rRNA species. Precursors of 5.8S and 28S rRNAs containing 5' extensions accumulate in mouse cells after siRNA-mediated knockdown of Xrn2, indicating similarity in the 5'-end maturation mechanisms between mammals and yeast. Strikingly, degradation of many aberrant pre-rRNA species, attributed mainly to 3' exonucleases in yeast studies, occurs 5' to 3' in mammalian cells and is mediated by Xrn2. Furthermore, depletion of Xrn2 reveals pre-rRNAs derived by cleavage events that deviate from the main processing pathway. We propose that probing of pre-rRNA maturation intermediates by exonucleases serves the dual function of generating mature rRNAs and suppressing suboptimal processing paths during ribosome assembly."xsd:string |
| http://purl.uniprot.org/citations/21036871 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkq1050"xsd:string |
| http://purl.uniprot.org/citations/21036871 | http://purl.uniprot.org/core/author | "Wang M."xsd:string |
| http://purl.uniprot.org/citations/21036871 | http://purl.uniprot.org/core/author | "Pestov D.G."xsd:string |
| http://purl.uniprot.org/citations/21036871 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21036871 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/21036871 | http://purl.uniprot.org/core/pages | "1811-1822"xsd:string |
| http://purl.uniprot.org/citations/21036871 | http://purl.uniprot.org/core/title | "5'-end surveillance by Xrn2 acts as a shared mechanism for mammalian pre-rRNA maturation and decay."xsd:string |
| http://purl.uniprot.org/citations/21036871 | http://purl.uniprot.org/core/volume | "39"xsd:string |
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