| http://purl.uniprot.org/citations/21037079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21037079 | http://www.w3.org/2000/01/rdf-schema#comment | "Telomere maintenance by either telomerase activity or the recombination-mediated alternative lengthening of telomeres (ALT) mechanism is a hallmark of cancer. Tumors that use ALT as their telomere maintenance mechanism are characterized by long telomeres of great heterogeneity in length and by specific nuclear structures of co-localized promyelocytic leukemia protein and telomere DNA, called ALT-associated promyelocytic leukemia bodies (APBs). Recent advances have revealed a direct role for APBs in telomere recombination in ALT-positive cells. In this study, we investigated the possibility that APBs could occur before the long 'alternatively' lengthened telomeres arise, particularly in low-grade tumors. We measured APBs, telomere length, and telomerase activity in 64 astrocytomas inclusive of grade 1-4 tumors. Almost all grade 1-3 tumors (93%) were APB-positive using published criteria. Grade 2-3 APB-positive tumors also had long telomeres and were confirmed as ALT positive. However, grade 1 tumors lacked long telomeres and were therefore classified as ALT negative, but positive for telomere-associated promyelocytic leukemia bodies (TPB). This is the first report of a TPB-positive but ALT-negative tumor, and suggests that low-grade tumors have the foundation for recombinational telomere repair, as in ALT. Further work is warranted to characterize the TPB-positive phenotype in other early malignancies, as well as to determine whether TPBs predispose to telomere maintenance by ALT."xsd:string |
| http://purl.uniprot.org/citations/21037079 | http://purl.org/dc/terms/identifier | "doi:10.2353/ajpath.2010.100468"xsd:string |
| http://purl.uniprot.org/citations/21037079 | http://purl.uniprot.org/core/author | "Chen Y.J."xsd:string |
| http://purl.uniprot.org/citations/21037079 | http://purl.uniprot.org/core/author | "Tan X."xsd:string |
| http://purl.uniprot.org/citations/21037079 | http://purl.uniprot.org/core/author | "MacFarlane M."xsd:string |
| http://purl.uniprot.org/citations/21037079 | http://purl.uniprot.org/core/author | "Sullivan M."xsd:string |
| http://purl.uniprot.org/citations/21037079 | http://purl.uniprot.org/core/author | "Hung N."xsd:string |
| http://purl.uniprot.org/citations/21037079 | http://purl.uniprot.org/core/author | "Royds J."xsd:string |
| http://purl.uniprot.org/citations/21037079 | http://purl.uniprot.org/core/author | "Wiles A."xsd:string |
| http://purl.uniprot.org/citations/21037079 | http://purl.uniprot.org/core/author | "Gifford-Garner J."xsd:string |
| http://purl.uniprot.org/citations/21037079 | http://purl.uniprot.org/core/author | "Slatter T."xsd:string |
| http://purl.uniprot.org/citations/21037079 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21037079 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/21037079 | http://purl.uniprot.org/core/pages | "2694-2700"xsd:string |
| http://purl.uniprot.org/citations/21037079 | http://purl.uniprot.org/core/title | "Pilocytic astrocytomas have telomere-associated promyelocytic leukemia bodies without alternatively lengthened telomeres."xsd:string |
| http://purl.uniprot.org/citations/21037079 | http://purl.uniprot.org/core/volume | "177"xsd:string |
| http://purl.uniprot.org/citations/21037079 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21037079 |
| http://purl.uniprot.org/citations/21037079 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21037079 |
| http://purl.uniprot.org/uniprot/#_A4VCI9-mappedCitation-21037079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21037079 |
| http://purl.uniprot.org/uniprot/#_B4DTK9-mappedCitation-21037079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21037079 |
| http://purl.uniprot.org/uniprot/#_B4DV67-mappedCitation-21037079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21037079 |
| http://purl.uniprot.org/uniprot/#_Q71RA7-mappedCitation-21037079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21037079 |
| http://purl.uniprot.org/uniprot/#_P29590-mappedCitation-21037079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21037079 |
| http://purl.uniprot.org/uniprot/#_Q05835-mappedCitation-21037079 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21037079 |