| http://purl.uniprot.org/citations/21040849 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21040849 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21040849 | http://www.w3.org/2000/01/rdf-schema#comment | "In contrast to its extensively studied intracellular roles, the molecular mechanisms by which extracellular Ca(2+) regulates the basal excitability of neurons are unclear. One mechanism is believed to be through Ca(2+)'s interaction with the negative charges on the cell membrane (the charge screening effect). Here we show that, in cultured hippocampal neurons, lowering [Ca(2+)](e) activates a NALCN channel-dependent Na(+)-leak current (I(L-Na)). The coupling between [Ca(2+)](e) and NALCN requires a Ca(2+)-sensing G protein-coupled receptor, an activation of G-proteins, an UNC80 protein that bridges NALCN to a large novel protein UNC79 in the same complex, and the last amino acid of NALCN's intracellular tail. In neurons from nalcn and unc79 knockout mice, I(L-Na) is insensitive to changes in [Ca(2+)](e), and reducing [Ca(2+)](e) fails to elicit the excitatory effects seen in the wild-type. Therefore, extracellular Ca(2+) influences neuronal excitability through the UNC79-UNC80-NALCN complex in a G protein-dependent fashion."xsd:string |
| http://purl.uniprot.org/citations/21040849 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2010.09.014"xsd:string |
| http://purl.uniprot.org/citations/21040849 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2010.09.014"xsd:string |
| http://purl.uniprot.org/citations/21040849 | http://purl.uniprot.org/core/author | "Nakayama M."xsd:string |
| http://purl.uniprot.org/citations/21040849 | http://purl.uniprot.org/core/author | "Nakayama M."xsd:string |
| http://purl.uniprot.org/citations/21040849 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/21040849 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/21040849 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/21040849 | http://purl.uniprot.org/core/author | "Zhang Q."xsd:string |
| http://purl.uniprot.org/citations/21040849 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/21040849 | http://purl.uniprot.org/core/author | "Wang H."xsd:string |
| http://purl.uniprot.org/citations/21040849 | http://purl.uniprot.org/core/author | "Lu B."xsd:string |
| http://purl.uniprot.org/citations/21040849 | http://purl.uniprot.org/core/author | "Lu B."xsd:string |
| http://purl.uniprot.org/citations/21040849 | http://purl.uniprot.org/core/author | "Ren D."xsd:string |
| http://purl.uniprot.org/citations/21040849 | http://purl.uniprot.org/core/author | "Ren D."xsd:string |
| http://purl.uniprot.org/citations/21040849 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21040849 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21040849 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/21040849 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/21040849 | http://purl.uniprot.org/core/pages | "488-499"xsd:string |
| http://purl.uniprot.org/citations/21040849 | http://purl.uniprot.org/core/pages | "488-499"xsd:string |
| http://purl.uniprot.org/citations/21040849 | http://purl.uniprot.org/core/title | "Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex."xsd:string |
| http://purl.uniprot.org/citations/21040849 | http://purl.uniprot.org/core/title | "Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex."xsd:string |