| http://purl.uniprot.org/citations/21040900 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21040900 | http://www.w3.org/2000/01/rdf-schema#comment | "Steroid hormones are known systemic regulators of multiple normal and cancerous tissues; however, whether or how they impact the fate and function of adult stem cells is unclear. In the Drosophila ovary, insulin signals modulate the proliferation and self-renewal of germline stem cells (GSCs), yet despite evidence that additional systemic factors control GSC activity, these have remained largely unknown. Here, we report that ecdysone, a steroid hormone structurally related to mammalian sex steroids, directly regulates adult GSC proliferation and self-renewal independently of insulin signaling. Ecdysone controls GSCs through a functional interaction with the chromatin remodeling factors ISWI, an intrinsic epigenetic factor required for GSC fate and activity, and Nurf301, the largest subunit of the ISWI-containing NURF chromatin remodeling complex. Our findings support a link between systemic steroid hormones and the intrinsic chromatin remodeling machinery as a potential mechanism to promote broad transcriptional programs required for adult stem cell self-renewal."xsd:string |
| http://purl.uniprot.org/citations/21040900 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.stem.2010.10.001"xsd:string |
| http://purl.uniprot.org/citations/21040900 | http://purl.uniprot.org/core/author | "Drummond-Barbosa D."xsd:string |
| http://purl.uniprot.org/citations/21040900 | http://purl.uniprot.org/core/author | "Ables E.T."xsd:string |
| http://purl.uniprot.org/citations/21040900 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21040900 | http://purl.uniprot.org/core/name | "Cell Stem Cell"xsd:string |
| http://purl.uniprot.org/citations/21040900 | http://purl.uniprot.org/core/pages | "581-592"xsd:string |
| http://purl.uniprot.org/citations/21040900 | http://purl.uniprot.org/core/title | "The steroid hormone ecdysone functions with intrinsic chromatin remodeling factors to control female germline stem cells in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/21040900 | http://purl.uniprot.org/core/volume | "7"xsd:string |
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