| http://purl.uniprot.org/citations/21041307 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21041307 | http://www.w3.org/2000/01/rdf-schema#comment | "Cl(-) channels in the apical membrane of biliary epithelial cells (BECs) provide the driving force for ductular bile formation. Although a cystic fibrosis transmembrane conductance regulator has been identified in BECs and contributes to secretion via secretin binding basolateral receptors and increasing [cAMP](i), an alternate Cl(-) secretory pathway has been identified that is activated via nucleotides (ATP, UTP) binding apical P2 receptors and increasing [Ca(2+)](i). The molecular identity of this Ca(2+)-activated Cl(-) channel is unknown. The present studies in human, mouse, and rat BECs provide evidence that TMEM16A is the operative channel and contributes to Ca(2+)-activated Cl(-) secretion in response to extracellular nucleotides. Furthermore, Cl(-) currents measured from BECs isolated from distinct areas of intrahepatic bile ducts revealed important functional differences. Large BECs, but not small BECs, exhibit cAMP-stimulated Cl(-) currents. However, both large and small BECs express TMEM16A and exhibit Ca(2+)-activated Cl(-) efflux in response to extracellular nucleotides. Incubation of polarized BEC monolayers with IL-4 increased TMEM16A protein expression, membrane localization, and transepithelial secretion (I(sc)). These studies represent the first molecular identification of an alternate, noncystic fibrosis transmembrane conductance regulator, Cl(-) channel in BECs and suggest that TMEM16A may be a potential target to modulate bile formation in the treatment of cholestatic liver disorders."xsd:string |
| http://purl.uniprot.org/citations/21041307 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.164970"xsd:string |
| http://purl.uniprot.org/citations/21041307 | http://purl.uniprot.org/core/author | "Dougherty M."xsd:string |
| http://purl.uniprot.org/citations/21041307 | http://purl.uniprot.org/core/author | "Ueno Y."xsd:string |
| http://purl.uniprot.org/citations/21041307 | http://purl.uniprot.org/core/author | "Rockey D.C."xsd:string |
| http://purl.uniprot.org/citations/21041307 | http://purl.uniprot.org/core/author | "Esser V."xsd:string |
| http://purl.uniprot.org/citations/21041307 | http://purl.uniprot.org/core/author | "Feranchak A.P."xsd:string |
| http://purl.uniprot.org/citations/21041307 | http://purl.uniprot.org/core/author | "Alpini G."xsd:string |
| http://purl.uniprot.org/citations/21041307 | http://purl.uniprot.org/core/author | "Glaser S.S."xsd:string |
| http://purl.uniprot.org/citations/21041307 | http://purl.uniprot.org/core/author | "Bugde A."xsd:string |
| http://purl.uniprot.org/citations/21041307 | http://purl.uniprot.org/core/author | "Dutta A.K."xsd:string |
| http://purl.uniprot.org/citations/21041307 | http://purl.uniprot.org/core/author | "Khimji A.K."xsd:string |
| http://purl.uniprot.org/citations/21041307 | http://purl.uniprot.org/core/author | "Kresge C."xsd:string |
| http://purl.uniprot.org/citations/21041307 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21041307 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/21041307 | http://purl.uniprot.org/core/pages | "766-776"xsd:string |
| http://purl.uniprot.org/citations/21041307 | http://purl.uniprot.org/core/title | "Identification and functional characterization of TMEM16A, a Ca2+-activated Cl- channel activated by extracellular nucleotides, in biliary epithelium."xsd:string |
| http://purl.uniprot.org/citations/21041307 | http://purl.uniprot.org/core/volume | "286"xsd:string |
| http://purl.uniprot.org/citations/21041307 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21041307 |
| http://purl.uniprot.org/citations/21041307 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21041307 |
| http://purl.uniprot.org/uniprot/#_A0A0G2QSF1-mappedCitation-21041307 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21041307 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MQF2-mappedCitation-21041307 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21041307 |
| http://purl.uniprot.org/uniprot/#_A0A348BSL7-mappedCitation-21041307 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21041307 |
| http://purl.uniprot.org/uniprot/#_B7Z8V1-mappedCitation-21041307 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21041307 |