| http://purl.uniprot.org/citations/21045009 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21045009 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21045009 | http://www.w3.org/2000/01/rdf-schema#comment | "Mycobacterium tuberculosis arabinogalactan (AG) is an essential cell wall component. It provides a molecular framework serving to connect peptidoglycan to the outer mycolic acid layer. The biosynthesis of the arabinan domains of AG and lipoarabinomannan (LAM) occurs via a combination of membrane bound arabinofuranosyltransferases, all of which utilize decaprenol-1-monophosphorabinose as a substrate. The source of arabinose ultimately destined for deposition into cell wall AG or LAM originates exclusively from phosphoribosyl-1-pyrophosphate (pRpp), a central metabolite which is also required for other essential metabolic processes, such as de novo purine and pyrimidine biosyntheses. In M. tuberculosis, a single pRpp synthetase enzyme (Mt-PrsA) is solely responsible for the generation of pRpp, by catalyzing the transfer of pyrophosphate from ATP to the C1 hydroxyl position of ribose-5-phosphate. Here, we report a detailed biochemical and biophysical study of Mt-PrsA, which exhibits the most rapid enzyme kinetics reported for a pRpp synthetase."xsd:string |
| http://purl.uniprot.org/citations/21045009 | http://purl.org/dc/terms/identifier | "doi:10.1093/glycob/cwq173"xsd:string |
| http://purl.uniprot.org/citations/21045009 | http://purl.org/dc/terms/identifier | "doi:10.1093/glycob/cwq173"xsd:string |
| http://purl.uniprot.org/citations/21045009 | http://purl.uniprot.org/core/author | "Eggeling L."xsd:string |
| http://purl.uniprot.org/citations/21045009 | http://purl.uniprot.org/core/author | "Eggeling L."xsd:string |
| http://purl.uniprot.org/citations/21045009 | http://purl.uniprot.org/core/author | "Besra G.S."xsd:string |
| http://purl.uniprot.org/citations/21045009 | http://purl.uniprot.org/core/author | "Besra G.S."xsd:string |
| http://purl.uniprot.org/citations/21045009 | http://purl.uniprot.org/core/author | "Alderwick L.J."xsd:string |
| http://purl.uniprot.org/citations/21045009 | http://purl.uniprot.org/core/author | "Alderwick L.J."xsd:string |
| http://purl.uniprot.org/citations/21045009 | http://purl.uniprot.org/core/author | "Lovering A.L."xsd:string |
| http://purl.uniprot.org/citations/21045009 | http://purl.uniprot.org/core/author | "Lovering A.L."xsd:string |
| http://purl.uniprot.org/citations/21045009 | http://purl.uniprot.org/core/author | "Lloyd A.J."xsd:string |
| http://purl.uniprot.org/citations/21045009 | http://purl.uniprot.org/core/author | "Lloyd A.J."xsd:string |
| http://purl.uniprot.org/citations/21045009 | http://purl.uniprot.org/core/author | "Lloyd G.S."xsd:string |
| http://purl.uniprot.org/citations/21045009 | http://purl.uniprot.org/core/author | "Lloyd G.S."xsd:string |
| http://purl.uniprot.org/citations/21045009 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21045009 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21045009 | http://purl.uniprot.org/core/name | "Glycobiology"xsd:string |
| http://purl.uniprot.org/citations/21045009 | http://purl.uniprot.org/core/name | "Glycobiology"xsd:string |
| http://purl.uniprot.org/citations/21045009 | http://purl.uniprot.org/core/pages | "410-425"xsd:string |
| http://purl.uniprot.org/citations/21045009 | http://purl.uniprot.org/core/pages | "410-425"xsd:string |
| http://purl.uniprot.org/citations/21045009 | http://purl.uniprot.org/core/title | "Biochemical characterization of the Mycobacterium tuberculosis phosphoribosyl-1-pyrophosphate synthetase."xsd:string |
| http://purl.uniprot.org/citations/21045009 | http://purl.uniprot.org/core/title | "Biochemical characterization of the Mycobacterium tuberculosis phosphoribosyl-1-pyrophosphate synthetase."xsd:string |