| http://purl.uniprot.org/citations/21045147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21045147 | http://www.w3.org/2000/01/rdf-schema#comment | "The mitotic kinase Aurora-A (Aur-A) is required to form the bipolar spindle and ensure accurate chromosome segregation before cell division. Aur-A dysregulation represents an oncogenic event that promotes tumor formation. Here, we report that Aur-A promotes breast cancer metastasis. Aur-A overexpression enhanced mammary cell migration by dephosphorylation and activation of cofilin, which facilitates actin reorganization and polymerization. Cofilin knockdown impaired Aur-A-driven cell migration and protrusion of the cell membrane. Conversely, overexpression of activated cofilin abrogated the effects of Aur-A knockdown on cell migration. Moreover, Aur-A overexpession increased the expression of the cofilin phosphatase Slingshot-1 (SSH1), contributing to cofilin activation and cell migration. We found that phosphatidylinositol 3-kinase (PI3K) inhibition blocked Aur-A-induced cofilin dephosphorylation, actin reorganization, and cell migration, suggesting crosstalk with PI3K signaling and a potential benefit of PI3K inhibition in tumors with deregulated Aur-A. Additionally, we found an association between Aur-A overexpression and cofilin activity in breast cancer tissues. Our findings indicate that activation of the cofilin-F-actin pathway contributes to tumor cell migration and metastasis enhanced by Aur-A, revealing a novel function for mitotic Aur-A kinase in tumor progression."xsd:string |
| http://purl.uniprot.org/citations/21045147 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-10-1246"xsd:string |
| http://purl.uniprot.org/citations/21045147 | http://purl.uniprot.org/core/author | "Liu Q."xsd:string |
| http://purl.uniprot.org/citations/21045147 | http://purl.uniprot.org/core/author | "Chen T.S."xsd:string |
| http://purl.uniprot.org/citations/21045147 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/21045147 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/21045147 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/21045147 | http://purl.uniprot.org/core/author | "Xiang J."xsd:string |
| http://purl.uniprot.org/citations/21045147 | http://purl.uniprot.org/core/author | "Wang L.H."xsd:string |
| http://purl.uniprot.org/citations/21045147 | http://purl.uniprot.org/core/author | "Yan M."xsd:string |
| http://purl.uniprot.org/citations/21045147 | http://purl.uniprot.org/core/author | "Xing D."xsd:string |
| http://purl.uniprot.org/citations/21045147 | http://purl.uniprot.org/core/author | "Kang Z."xsd:string |
| http://purl.uniprot.org/citations/21045147 | http://purl.uniprot.org/core/author | "Chen J.N."xsd:string |
| http://purl.uniprot.org/citations/21045147 | http://purl.uniprot.org/core/author | "Yue C.F."xsd:string |
| http://purl.uniprot.org/citations/21045147 | http://purl.uniprot.org/core/author | "Zheng F.M."xsd:string |
| http://purl.uniprot.org/citations/21045147 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21045147 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/21045147 | http://purl.uniprot.org/core/pages | "9118-9128"xsd:string |
| http://purl.uniprot.org/citations/21045147 | http://purl.uniprot.org/core/title | "The mitotic kinase Aurora-A induces mammary cell migration and breast cancer metastasis by activating the Cofilin-F-actin pathway."xsd:string |
| http://purl.uniprot.org/citations/21045147 | http://purl.uniprot.org/core/volume | "70"xsd:string |
| http://purl.uniprot.org/citations/21045147 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21045147 |
| http://purl.uniprot.org/citations/21045147 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21045147 |
| http://purl.uniprot.org/uniprot/#_Q1KLZ0-mappedCitation-21045147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21045147 |
| http://purl.uniprot.org/uniprot/#_A0A510GJR4-mappedCitation-21045147 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21045147 |