| http://purl.uniprot.org/citations/21048983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21048983 | http://www.w3.org/2000/01/rdf-schema#comment | "Chromosomal translocations between loci encoding MALT1 and c-IAP2 are common in MALT lymphomas. The resulting fusion proteins lack the c-IAP2 RING domain, the region responsible for its ubiquitin protein ligase (E3) activity. Ectopic expression of the fusion protein activates the canonical NF-κB signaling cascade, but how it does so is controversial and how it promotes MALT lymphoma is unknown. Considering recent reports implicating c-IAP1 and c-IAP2 E3 activity in repression of non-canonical NF-κB signaling, we asked if the c-IAP2/MALT fusion protein can initiate non-canonical NF-κB activation. Here we show that in addition to canonical activation, the fusion protein stabilizes NIK and activates non-canonical NF-κB. Canonical but not non-canonical activation depended on MALT1 paracaspase activity, and expression of E3-inactive c-IAP2 activated non-canonical NF-κB. Mice in which endogenous c-IAP2 was replaced with an E3-inactive mutant accumulated abnormal B cells with elevated non-canonical NF-κB and had increased numbers of B cells with a marginal zone phenotype, gut-associated lymphoid hyperplasia, and other features of MALT lymphoma. Thus, the c-IAP2/MALT1 fusion protein activates NF-κB by two distinct mechanisms, and loss of c-IAP2 E3 activity in vivo is sufficient to induce abnormalities common to MALT lymphoma."xsd:string |
| http://purl.uniprot.org/citations/21048983 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pbio.1000518"xsd:string |
| http://purl.uniprot.org/citations/21048983 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/21048983 | http://purl.uniprot.org/core/author | "Ashwell J.D."xsd:string |
| http://purl.uniprot.org/citations/21048983 | http://purl.uniprot.org/core/author | "Conze D.B."xsd:string |
| http://purl.uniprot.org/citations/21048983 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21048983 | http://purl.uniprot.org/core/name | "PLoS Biol"xsd:string |
| http://purl.uniprot.org/citations/21048983 | http://purl.uniprot.org/core/pages | "e1000518"xsd:string |
| http://purl.uniprot.org/citations/21048983 | http://purl.uniprot.org/core/title | "Non-canonical NF-kappaB activation and abnormal B cell accumulation in mice expressing ubiquitin protein ligase-inactive c-IAP2."xsd:string |
| http://purl.uniprot.org/citations/21048983 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/21048983 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21048983 |
| http://purl.uniprot.org/citations/21048983 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21048983 |
| http://purl.uniprot.org/uniprot/#_E0CZ20-mappedCitation-21048983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21048983 |
| http://purl.uniprot.org/uniprot/#_E0CZ68-mappedCitation-21048983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21048983 |
| http://purl.uniprot.org/uniprot/#_A2CGA3-mappedCitation-21048983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21048983 |
| http://purl.uniprot.org/uniprot/#_A2CGA5-mappedCitation-21048983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21048983 |
| http://purl.uniprot.org/uniprot/#_A4L9Q2-mappedCitation-21048983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21048983 |
| http://purl.uniprot.org/uniprot/#_A0A494B901-mappedCitation-21048983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21048983 |
| http://purl.uniprot.org/uniprot/#_A0A494BA44-mappedCitation-21048983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21048983 |
| http://purl.uniprot.org/uniprot/#_F7BQL8-mappedCitation-21048983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21048983 |
| http://purl.uniprot.org/uniprot/#_O08863-mappedCitation-21048983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21048983 |
| http://purl.uniprot.org/uniprot/#_Q4U113-mappedCitation-21048983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21048983 |
| http://purl.uniprot.org/uniprot/#_Q921N0-mappedCitation-21048983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21048983 |
| http://purl.uniprot.org/uniprot/#_Q8BTL4-mappedCitation-21048983 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21048983 |