| http://purl.uniprot.org/citations/21051640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21051640 | http://www.w3.org/2000/01/rdf-schema#comment | "Protein synthesis requires several guanosine triphosphatase (GTPase) factors, including elongation factor Tu (EF-Tu), which delivers aminoacyl-transfer RNAs (tRNAs) to the ribosome. To understand how the ribosome triggers GTP hydrolysis in translational GTPases, we have determined the crystal structure of EF-Tu and aminoacyl-tRNA bound to the ribosome with a GTP analog, to 3.2 angstrom resolution. EF-Tu is in its active conformation, the switch I loop is ordered, and the catalytic histidine is coordinating the nucleophilic water in position for inline attack on the γ-phosphate of GTP. This activated conformation is due to a critical and conserved interaction of the histidine with A2662 of the sarcin-ricin loop of the 23S ribosomal RNA. The structure suggests a universal mechanism for GTPase activation and hydrolysis in translational GTPases on the ribosome."xsd:string |
| http://purl.uniprot.org/citations/21051640 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1194460"xsd:string |
| http://purl.uniprot.org/citations/21051640 | http://purl.uniprot.org/core/author | "Ramakrishnan V."xsd:string |
| http://purl.uniprot.org/citations/21051640 | http://purl.uniprot.org/core/author | "Schmeing T.M."xsd:string |
| http://purl.uniprot.org/citations/21051640 | http://purl.uniprot.org/core/author | "Kelley A.C."xsd:string |
| http://purl.uniprot.org/citations/21051640 | http://purl.uniprot.org/core/author | "Voorhees R.M."xsd:string |
| http://purl.uniprot.org/citations/21051640 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21051640 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/21051640 | http://purl.uniprot.org/core/pages | "835-838"xsd:string |
| http://purl.uniprot.org/citations/21051640 | http://purl.uniprot.org/core/title | "The mechanism for activation of GTP hydrolysis on the ribosome."xsd:string |
| http://purl.uniprot.org/citations/21051640 | http://purl.uniprot.org/core/volume | "330"xsd:string |
| http://purl.uniprot.org/citations/21051640 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21051640 |
| http://purl.uniprot.org/citations/21051640 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21051640 |
| http://purl.uniprot.org/uniprot/#_P62659-mappedCitation-21051640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21051640 |
| http://purl.uniprot.org/uniprot/#_P62667-mappedCitation-21051640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21051640 |
| http://purl.uniprot.org/uniprot/#_P35871-mappedCitation-21051640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21051640 |
| http://purl.uniprot.org/uniprot/#_P0DOY6-mappedCitation-21051640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21051640 |
| http://purl.uniprot.org/uniprot/#_P0DOY7-mappedCitation-21051640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21051640 |
| http://purl.uniprot.org/uniprot/#_P0DOY8-mappedCitation-21051640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21051640 |
| http://purl.uniprot.org/uniprot/#_P0DOY9-mappedCitation-21051640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21051640 |
| http://purl.uniprot.org/uniprot/#_P17291-mappedCitation-21051640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21051640 |
| http://purl.uniprot.org/uniprot/#_P80339-mappedCitation-21051640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21051640 |
| http://purl.uniprot.org/uniprot/#_P80340-mappedCitation-21051640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21051640 |
| http://purl.uniprot.org/uniprot/#_P80371-mappedCitation-21051640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21051640 |