| http://purl.uniprot.org/citations/21055430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21055430 | http://www.w3.org/2000/01/rdf-schema#comment | "Orexin (ORX) plays a critical role in reward-seeking behavior for natural rewards and drugs of abuse. The mesolimbic dopamine (DA) pathway that projects into the nucleus accumbens (NAc) from the ventral tegmental area is deeply involved in the neural mechanisms underlying reward, drug abuse and motivation. A recent study demonstrated that ORX-immunopositive fibers densely project into the shell of the NAc (NAcSh), suggesting that the NAcSh might be a site of the interaction between the ORXergic and DAergic systems for reward-seeking behavior. Therefore, the electrophysiological effects of ORX-B and DA on NAcSh neurons were examined extracellularly in rat brain slice preparations. ORX-B excited approximately 78% of neurons tested and inhibited 4%, whereas DA excited 50% and inhibited 22% of NAcSh neurons. These excitations and inhibitions persisted during synaptic blockade in a low-Ca(2+)/high-Mg(2+) solution. DA-induced excitation was attenuated by SCH23390 or sulpiride, whereas DA-induced inhibition was suppressed by sulpiride. Of the neurons that were excited by ORX-B, 71% and 18% were excited and inhibited by DA, respectively. In 63% of neurons that were excited by ORX-B, the simultaneous application of ORX-B and DA increased the firing rate to two times greater than ORX-B alone, whereas, the simultaneous application significantly decreased the neuronal firing rate by 73% in the remaining 37% compared to ORX-B. These results suggest that an interaction between the ORXergic and DAergic systems occurs in the NAcSh and that the NAcSh is involved in the neural mechanisms in which ORX participates in the regulation of reward-seeking behavior."xsd:string |
| http://purl.uniprot.org/citations/21055430 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.peptides.2010.10.023"xsd:string |
| http://purl.uniprot.org/citations/21055430 | http://purl.uniprot.org/core/author | "Kim J."xsd:string |
| http://purl.uniprot.org/citations/21055430 | http://purl.uniprot.org/core/author | "Mori K."xsd:string |
| http://purl.uniprot.org/citations/21055430 | http://purl.uniprot.org/core/author | "Sasaki K."xsd:string |
| http://purl.uniprot.org/citations/21055430 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21055430 | http://purl.uniprot.org/core/name | "Peptides"xsd:string |
| http://purl.uniprot.org/citations/21055430 | http://purl.uniprot.org/core/pages | "246-252"xsd:string |
| http://purl.uniprot.org/citations/21055430 | http://purl.uniprot.org/core/title | "Electrophysiological effects of orexin-B and dopamine on rat nucleus accumbens shell neurons in vitro."xsd:string |
| http://purl.uniprot.org/citations/21055430 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/21055430 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21055430 |
| http://purl.uniprot.org/citations/21055430 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21055430 |
| http://purl.uniprot.org/uniprot/#_A6HJ59-mappedCitation-21055430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21055430 |
| http://purl.uniprot.org/uniprot/#_A6HJ60-mappedCitation-21055430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21055430 |
| http://purl.uniprot.org/uniprot/#_O55232-mappedCitation-21055430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21055430 |
| http://purl.uniprot.org/uniprot/A6HJ59 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21055430 |
| http://purl.uniprot.org/uniprot/A6HJ60 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21055430 |
| http://purl.uniprot.org/uniprot/O55232 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21055430 |