| http://purl.uniprot.org/citations/21055733 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21055733 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-10 transcripts were expressed in 14/15 primary breast adenocarcinomas and in 5/8 established breast tumor lines. Immunohistochemistry and immunoprecipitation from lysates and supernatants revealed that established breast tumor lines produced IL-10 protein. Immunohistochemistry revealed that IL-10 is localized to tumor cells of primary breast adenocarcinomas and to occasional infiltrating MNC. Established breast tumor cell lines expressed IL-12p40 transcripts (6/8) and protein (4/7) and IL-12p35 transcripts (6/7). Using two sandwich ELISAs, specific, respectively, for IL-12p40 and IL-12p70 proteins, we demonstrated that established breast tumor cell lines produce IL-12p40 monomer/homodimer, but not IL-12p70. Positive staining for IL-12p70 in primary breast adenocarcinomas was found only in MNC infiltrating the tumor while tumor cells were negative. IL-12p40 homodimer/monomer inhibit as antagonists IL-12 or IL-23, although they may also act as agonists and positive regulators. Also, primary breast adenocarcinomas (15/15) and established breast tumor cell lines (6/8) expressed TGF-β1 transcripts. IL-10, IL-12p40 and TGF-β1 may inhibit substantially the anti-tumor immune response."xsd:string |
| http://purl.uniprot.org/citations/21055733 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellimm.2010.09.010"xsd:string |
| http://purl.uniprot.org/citations/21055733 | http://purl.uniprot.org/core/author | "Schwarting R."xsd:string |
| http://purl.uniprot.org/citations/21055733 | http://purl.uniprot.org/core/author | "Katsetos C.D."xsd:string |
| http://purl.uniprot.org/citations/21055733 | http://purl.uniprot.org/core/author | "Salgame P."xsd:string |
| http://purl.uniprot.org/citations/21055733 | http://purl.uniprot.org/core/author | "Platsoucas C.D."xsd:string |
| http://purl.uniprot.org/citations/21055733 | http://purl.uniprot.org/core/author | "Wolfson A."xsd:string |
| http://purl.uniprot.org/citations/21055733 | http://purl.uniprot.org/core/author | "Heckel M.C."xsd:string |
| http://purl.uniprot.org/citations/21055733 | http://purl.uniprot.org/core/author | "Slachta C.A."xsd:string |
| http://purl.uniprot.org/citations/21055733 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21055733 | http://purl.uniprot.org/core/name | "Cell Immunol"xsd:string |
| http://purl.uniprot.org/citations/21055733 | http://purl.uniprot.org/core/pages | "143-153"xsd:string |
| http://purl.uniprot.org/citations/21055733 | http://purl.uniprot.org/core/title | "Human breast tumor cells express IL-10 and IL-12p40 transcripts and proteins, but do not produce IL-12p70."xsd:string |
| http://purl.uniprot.org/citations/21055733 | http://purl.uniprot.org/core/volume | "266"xsd:string |
| http://purl.uniprot.org/citations/21055733 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21055733 |
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