| http://purl.uniprot.org/citations/21055811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21055811 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21055811 | http://www.w3.org/2000/01/rdf-schema#comment | "The structure of the complement-binding domain of Staphylococcus aureus protein Sbi (Sbi-IV) in complex with ligand C3d is presented. The 1.7Å resolution structure reveals the molecular details of the recognition of thioester-containing fragment C3d of the central complement component C3, involving interactions between residues of Sbi-IV helix α2 and the acidic concave surface of C3d. The complex provides a structural basis for the binding preference of Sbi for native C3 over C3b and explains how Sbi-IV inhibits the interaction between C3d and complement receptor 2. A second C3d binding site on Sbi-IV is identified in the crystal structure that is not observed in related S. aureus C3 inhibitors Efb-C and Ehp. This binding mode perhaps hints as to how Sbi-IV, as part of Sbi, forms a C3b-Sbi adduct and causes futile consumption of C3, an extraordinary aspect of Sbi function that is not shared by any other known Staphylococcal complement inhibitor."xsd:string |
| http://purl.uniprot.org/citations/21055811 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molimm.2010.09.017"xsd:string |
| http://purl.uniprot.org/citations/21055811 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molimm.2010.09.017"xsd:string |
| http://purl.uniprot.org/citations/21055811 | http://purl.uniprot.org/core/author | "Bagby S."xsd:string |
| http://purl.uniprot.org/citations/21055811 | http://purl.uniprot.org/core/author | "Bagby S."xsd:string |
| http://purl.uniprot.org/citations/21055811 | http://purl.uniprot.org/core/author | "Upadhyay A."xsd:string |
| http://purl.uniprot.org/citations/21055811 | http://purl.uniprot.org/core/author | "Upadhyay A."xsd:string |
| http://purl.uniprot.org/citations/21055811 | http://purl.uniprot.org/core/author | "Svergun D.I."xsd:string |
| http://purl.uniprot.org/citations/21055811 | http://purl.uniprot.org/core/author | "Svergun D.I."xsd:string |
| http://purl.uniprot.org/citations/21055811 | http://purl.uniprot.org/core/author | "Crennell S."xsd:string |
| http://purl.uniprot.org/citations/21055811 | http://purl.uniprot.org/core/author | "Crennell S."xsd:string |
| http://purl.uniprot.org/citations/21055811 | http://purl.uniprot.org/core/author | "Clark E.A."xsd:string |
| http://purl.uniprot.org/citations/21055811 | http://purl.uniprot.org/core/author | "Clark E.A."xsd:string |
| http://purl.uniprot.org/citations/21055811 | http://purl.uniprot.org/core/author | "Mackay J.D."xsd:string |
| http://purl.uniprot.org/citations/21055811 | http://purl.uniprot.org/core/author | "Mackay J.D."xsd:string |
| http://purl.uniprot.org/citations/21055811 | http://purl.uniprot.org/core/author | "Zozulya A.V."xsd:string |
| http://purl.uniprot.org/citations/21055811 | http://purl.uniprot.org/core/author | "Zozulya A.V."xsd:string |
| http://purl.uniprot.org/citations/21055811 | http://purl.uniprot.org/core/author | "van den Elsen J.M."xsd:string |
| http://purl.uniprot.org/citations/21055811 | http://purl.uniprot.org/core/author | "van den Elsen J.M."xsd:string |
| http://purl.uniprot.org/citations/21055811 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21055811 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21055811 | http://purl.uniprot.org/core/name | "Mol. Immunol."xsd:string |
| http://purl.uniprot.org/citations/21055811 | http://purl.uniprot.org/core/name | "Mol. Immunol."xsd:string |