| http://purl.uniprot.org/citations/21056555 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21056555 | http://www.w3.org/2000/01/rdf-schema#comment | "We previously reported that IRF-9/STAT2 functional interaction could drive the expression of retinoic acid-induced gene G (RIG-G), independently of STAT1 and the classical JAK-STAT pathway, providing a novel alternative pathway for interferons (IFN) to mediate their multiple biological properties. In addition, we also found that IRF-1 could regulate RIG-G induction as well as the expression of IRF-9 and STAT2 in some cases. But the mechanisms by which IRF-1 exerted its action remained to be elucidated. Here, we showed that STAT1 could significantly enhance the effects of the IRF-9/STAT2 complex or IRF-1 on RIG-G induction through an activated JAK-STAT pathway, though it was not essential for RIG-G expression. In STAT1-deficient U3A cells, IRF-1 could induce RIG-G expression via the IFN-stimulated response elements in the RIG-G gene promoter, but it failed to upregulate IRF-9 and STAT2 unless the U3A cells were reconstituted by exogenous STAT1. In STAT1-expressing cells, IRF-1 indirectly activated RIG-G expression through an IRF-9/STAT2-dependent manner. Taken together, we concluded that the expression of RIG-G was independent on the classical JAK-STAT pathway, but could be greatly increased by it. This work will be of great benefit to us for a better understanding of the mechanisms on RIG-G gene expression regulation."xsd:string |
| http://purl.uniprot.org/citations/21056555 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.yexcr.2010.10.025"xsd:string |
| http://purl.uniprot.org/citations/21056555 | http://purl.uniprot.org/core/author | "Li D."xsd:string |
| http://purl.uniprot.org/citations/21056555 | http://purl.uniprot.org/core/author | "Zhang Z.L."xsd:string |
| http://purl.uniprot.org/citations/21056555 | http://purl.uniprot.org/core/author | "Jia P.M."xsd:string |
| http://purl.uniprot.org/citations/21056555 | http://purl.uniprot.org/core/author | "Pan X.R."xsd:string |
| http://purl.uniprot.org/citations/21056555 | http://purl.uniprot.org/core/author | "Tong J.H."xsd:string |
| http://purl.uniprot.org/citations/21056555 | http://purl.uniprot.org/core/author | "Xu G.P."xsd:string |
| http://purl.uniprot.org/citations/21056555 | http://purl.uniprot.org/core/author | "Lou Y.J."xsd:string |
| http://purl.uniprot.org/citations/21056555 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21056555 | http://purl.uniprot.org/core/name | "Exp Cell Res"xsd:string |
| http://purl.uniprot.org/citations/21056555 | http://purl.uniprot.org/core/pages | "513-520"xsd:string |
| http://purl.uniprot.org/citations/21056555 | http://purl.uniprot.org/core/title | "Intact JAK-STAT signaling pathway is a prerequisite for STAT1 to reinforce the expression of RIG-G gene."xsd:string |
| http://purl.uniprot.org/citations/21056555 | http://purl.uniprot.org/core/volume | "317"xsd:string |
| http://purl.uniprot.org/citations/21056555 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21056555 |
| http://purl.uniprot.org/citations/21056555 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21056555 |
| http://purl.uniprot.org/uniprot/#_A0A7P0T7D6-mappedCitation-21056555 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21056555 |
| http://purl.uniprot.org/uniprot/#_A0A510GDC6-mappedCitation-21056555 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21056555 |
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| http://purl.uniprot.org/uniprot/#_B4DLS7-mappedCitation-21056555 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21056555 |
| http://purl.uniprot.org/uniprot/#_P42224-mappedCitation-21056555 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21056555 |
| http://purl.uniprot.org/uniprot/#_O14879-mappedCitation-21056555 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21056555 |
| http://purl.uniprot.org/uniprot/#_Q67C41-mappedCitation-21056555 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21056555 |