| http://purl.uniprot.org/citations/2105931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2105931 | http://www.w3.org/2000/01/rdf-schema#comment | "The biochemical properties of three stimulatory guanine nucleotide-binding protein (G-protein) alpha subunits, the large and small forms of Gs, Gs-l (52 kDa) and Gs-s (45 kDa), and the olfactory specific G-protein, Golf, have been compared. Complementary DNAs (cDNAs) encoding each alpha subunit were independently expressed in a mammalian cell line deficient in endogenous stimulatory G-proteins (S49 cyc-kin-). Gs-l and Gs-s respond similarly to activation by the beta-adrenergic agonist isoproterenol (EC50 = 80 and 60 nM, respectively) and the receptor-independent G-protein activators guanosine 5-O-3-(thio)triphosphate) (GTP gamma S) and AlF-4. The ability of Golf to interact with the beta-adrenergic receptor was also examined. Surprisingly, Golf interacts with beta-adrenergic receptors and is activated by isoproterenol (EC50 = 120 nM). All three G-proteins respond similarly to treatment with different alpha, beta, and gamma thiophosphoryl analogs of GTP. Specifically, (R)-GTP alpha S and GTP gamma S activate each G-protein, whereas (S)-GTP alpha S and (R)- or (S)-GTP beta S are inactive. In addition, similar to Gs alpha, Golf alpha is covalently modified and constitutively activated by cholera toxin. These studies demonstrate that all three stimulatory G-proteins are functionally and structurally similar, however, subtle differences between Golf and the two forms of Gs appear to modulate their interactions with receptors."xsd:string |
| http://purl.uniprot.org/citations/2105931 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(19)39853-9"xsd:string |
| http://purl.uniprot.org/citations/2105931 | http://purl.uniprot.org/core/author | "Reed R.R."xsd:string |
| http://purl.uniprot.org/citations/2105931 | http://purl.uniprot.org/core/author | "Jones D.T."xsd:string |
| http://purl.uniprot.org/citations/2105931 | http://purl.uniprot.org/core/author | "Bourne H.R."xsd:string |
| http://purl.uniprot.org/citations/2105931 | http://purl.uniprot.org/core/author | "Masters S.B."xsd:string |
| http://purl.uniprot.org/citations/2105931 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2105931 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/2105931 | http://purl.uniprot.org/core/pages | "2671-2676"xsd:string |
| http://purl.uniprot.org/citations/2105931 | http://purl.uniprot.org/core/title | "Biochemical characterization of three stimulatory GTP-binding proteins. The large and small forms of Gs and the olfactory-specific G-protein, Golf."xsd:string |
| http://purl.uniprot.org/citations/2105931 | http://purl.uniprot.org/core/volume | "265"xsd:string |
| http://purl.uniprot.org/citations/2105931 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2105931 |
| http://purl.uniprot.org/citations/2105931 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/2105931 |
| http://purl.uniprot.org/uniprot/#_P0C617-mappedCitation-2105931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2105931 |
| http://purl.uniprot.org/uniprot/#_P0C7N1-mappedCitation-2105931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2105931 |
| http://purl.uniprot.org/uniprot/#_Q15619-mappedCitation-2105931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2105931 |
| http://purl.uniprot.org/uniprot/#_A4D2G3-mappedCitation-2105931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2105931 |
| http://purl.uniprot.org/uniprot/#_A6NND4-mappedCitation-2105931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2105931 |
| http://purl.uniprot.org/uniprot/#_P58170-mappedCitation-2105931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2105931 |
| http://purl.uniprot.org/uniprot/#_P58180-mappedCitation-2105931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2105931 |
| http://purl.uniprot.org/uniprot/#_O95371-mappedCitation-2105931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2105931 |
| http://purl.uniprot.org/uniprot/#_Q13607-mappedCitation-2105931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2105931 |
| http://purl.uniprot.org/uniprot/#_O76001-mappedCitation-2105931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2105931 |
| http://purl.uniprot.org/uniprot/#_O76002-mappedCitation-2105931 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2105931 |