| http://purl.uniprot.org/citations/2105940 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2105940 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2105940 | http://www.w3.org/2000/01/rdf-schema#comment | "Chromogranin A (secretory protein-I) is an acidic, sulfated glycoprotein found in secretory granules of most endocrine cells but not in exocrine or epithelial cells. Parathyroid chromogranin A is sulfated on tyrosine residues, whereas adrenal chromogranin A appears to be sulfated mainly on oligosaccharide residues. Chromogranin B, on the other hand, is tyrosine-sulfated in the bovine adrenal whereas this protein is absent from the parathyroid. The role of this tissue- or species-specific sulfation of chromogranin is not known. Tyrosine sulfation is a common post-translational modification of proteins in the exocytotic pathway and has been suggested to play a role in the sorting or intracellular transport of secretory proteins. To test this, porcine parathyroid tissue slices were metabolically labeled with 35SO4 and [3H]Lys, and the tissue and incubation medium analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, immunoblotting, and immunoprecipitation with chromogranin A-specific antiserum or by radioimmunoassay for parathormone. Secretion of total and 3H-labeled chromogranin A was about 3- and 7-fold higher, respectively, at 0.5 mM than at 3.0 mM Ca2+, and secretion of 35SO4-labeled chromogranin A was 67-fold higher. This indicates that either sulfated chromogranin A is directed primarily to the Ca2+-regulated pathway or that sulfation occurs following sorting to this pathway. Sodium chlorate (1-10 mM) inhibited sulfation in a dose-dependent manner by up to 95% but it had no effect on the onset or rate of chromogranin A secretion. These data indicate that regulated secretion of parathyroid chromogranin A does not require sulfation of tyrosine residues."xsd:string |
| http://purl.uniprot.org/citations/2105940 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(19)39725-x"xsd:string |
| http://purl.uniprot.org/citations/2105940 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(19)39725-x"xsd:string |
| http://purl.uniprot.org/citations/2105940 | http://purl.uniprot.org/core/author | "Cohn D.V."xsd:string |
| http://purl.uniprot.org/citations/2105940 | http://purl.uniprot.org/core/author | "Cohn D.V."xsd:string |
| http://purl.uniprot.org/citations/2105940 | http://purl.uniprot.org/core/author | "Gorr S.U."xsd:string |
| http://purl.uniprot.org/citations/2105940 | http://purl.uniprot.org/core/author | "Gorr S.U."xsd:string |
| http://purl.uniprot.org/citations/2105940 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2105940 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2105940 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/2105940 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/2105940 | http://purl.uniprot.org/core/pages | "3012-3016"xsd:string |
| http://purl.uniprot.org/citations/2105940 | http://purl.uniprot.org/core/pages | "3012-3016"xsd:string |
| http://purl.uniprot.org/citations/2105940 | http://purl.uniprot.org/core/title | "Secretion of sulfated and nonsulfated forms of parathyroid chromogranin A (secretory protein-I)."xsd:string |
| http://purl.uniprot.org/citations/2105940 | http://purl.uniprot.org/core/title | "Secretion of sulfated and nonsulfated forms of parathyroid chromogranin A (secretory protein-I)."xsd:string |
| http://purl.uniprot.org/citations/2105940 | http://purl.uniprot.org/core/volume | "265"xsd:string |
| http://purl.uniprot.org/citations/2105940 | http://purl.uniprot.org/core/volume | "265"xsd:string |
| http://purl.uniprot.org/citations/2105940 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2105940 |
| http://purl.uniprot.org/citations/2105940 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2105940 |
| http://purl.uniprot.org/citations/2105940 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/2105940 |
| http://purl.uniprot.org/citations/2105940 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/2105940 |
| http://purl.uniprot.org/uniprot/P04404 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/2105940 |
| http://purl.uniprot.org/uniprot/P04404#attribution-53BBBE2958A9EE0556B13951FB5560E5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/2105940 |