| http://purl.uniprot.org/citations/21059856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21059856 | http://www.w3.org/2000/01/rdf-schema#comment | "In myeloid dendritic cells (mDCs), TLR3 is expressed in the endosomal membrane and interacts with the adaptor toll/interleukin 1 receptor homology domain-containing adaptor molecule 1 (TICAM-1; TRIF). TICAM-1 signals culminate in interferon (IFN) regulatory factor (IRF) 3 activation. Co-culture of mDC pretreated with the TLR3 ligand polyI:C and natural killer (NK) cells resulted in NK cell activation. This activation was triggered by cell-to-cell contact but not cytokines. Using expression profiling and gain/loss-of-function analyses of mDC genes, we tried to identify a TICAM-1-inducing membrane protein that participates in mDC-mediated NK activation. Of the nine candidates screened, one contained a tetraspanin-like sequence and satisfied the screening criteria. The protein, referred to as IRF-3-dependent NK-activating molecule (INAM), functioned in both the mDC and NK cell to facilitate NK activation. In the mDC, TICAM-1, IFN promoter stimulator 1, and IRF-3, but not IRF-7, were required for mDC-mediated NK activation. INAM was minimally expressed on NK cells, was up-regulated in response to polyI:C, and contributed to mDC-NK reciprocal activation via its cytoplasmic tail, which was crucial for the activation signal in NK cells. Adoptive transfer of INAM-expressing mDCs into mice implanted with NK-sensitive tumors caused NK-mediated tumor regression. We identify a new pathway for mDC-NK contact-mediated NK activation that is governed by a TLR signal-derived membrane molecule."xsd:string |
| http://purl.uniprot.org/citations/21059856 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20091573"xsd:string |
| http://purl.uniprot.org/citations/21059856 | http://purl.uniprot.org/core/author | "Matsumoto K."xsd:string |
| http://purl.uniprot.org/citations/21059856 | http://purl.uniprot.org/core/author | "Matsumoto M."xsd:string |
| http://purl.uniprot.org/citations/21059856 | http://purl.uniprot.org/core/author | "Saito H."xsd:string |
| http://purl.uniprot.org/citations/21059856 | http://purl.uniprot.org/core/author | "Taniguchi T."xsd:string |
| http://purl.uniprot.org/citations/21059856 | http://purl.uniprot.org/core/author | "Azuma M."xsd:string |
| http://purl.uniprot.org/citations/21059856 | http://purl.uniprot.org/core/author | "Iwabuchi K."xsd:string |
| http://purl.uniprot.org/citations/21059856 | http://purl.uniprot.org/core/author | "Seya T."xsd:string |
| http://purl.uniprot.org/citations/21059856 | http://purl.uniprot.org/core/author | "Oshiumi H."xsd:string |
| http://purl.uniprot.org/citations/21059856 | http://purl.uniprot.org/core/author | "Ebihara T."xsd:string |
| http://purl.uniprot.org/citations/21059856 | http://purl.uniprot.org/core/author | "Kasamatsu J."xsd:string |
| http://purl.uniprot.org/citations/21059856 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21059856 | http://purl.uniprot.org/core/name | "J Exp Med"xsd:string |
| http://purl.uniprot.org/citations/21059856 | http://purl.uniprot.org/core/pages | "2675-2687"xsd:string |
| http://purl.uniprot.org/citations/21059856 | http://purl.uniprot.org/core/title | "Identification of a polyI:C-inducible membrane protein that participates in dendritic cell-mediated natural killer cell activation."xsd:string |
| http://purl.uniprot.org/citations/21059856 | http://purl.uniprot.org/core/volume | "207"xsd:string |
| http://purl.uniprot.org/citations/21059856 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21059856 |
| http://purl.uniprot.org/citations/21059856 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21059856 |
| http://purl.uniprot.org/uniprot/Q80UF7#attribution-4090D48B025B440E7F7512D215D2ABAE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21059856 |
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| http://purl.uniprot.org/uniprot/#_P70671-mappedCitation-21059856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21059856 |
| http://purl.uniprot.org/uniprot/#_A0A140LHE6-mappedCitation-21059856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21059856 |
| http://purl.uniprot.org/uniprot/#_A0A140LHT8-mappedCitation-21059856 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21059856 |