| http://purl.uniprot.org/citations/21061439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21061439 | http://www.w3.org/2000/01/rdf-schema#comment | "While it is well established that CD8(+) T cells generated in the absence of CD4(+) T cells mediate defective recall responses, the mechanism by which CD4(+) T cells confer help in the generation of CD8(+) T-cell responses remains poorly understood. To determine whether CD4(+) T-cell-derived IL-21 is an important regulator of CD8(+) T-cell responses in help-dependent and -independent viral infections, we examined these responses in the IL-21Rα(-/-) mouse model. We show that IL-21 has a role in primary CD8(+) T-cell responses and in recall CD8(+) T-cell responses in help-dependent viral infections. This effect is due to a direct action of IL-21 in enhancing the proliferation of virus-specific CD8(+) T cells and reducing their TRAIL expression. These findings indicate that IL-21 is an important mediator of CD4(+) T-cell help to CD8(+) T cells."xsd:string |
| http://purl.uniprot.org/citations/21061439 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200939939"xsd:string |
| http://purl.uniprot.org/citations/21061439 | http://purl.uniprot.org/core/author | "Letvin N.L."xsd:string |
| http://purl.uniprot.org/citations/21061439 | http://purl.uniprot.org/core/author | "Panas M.W."xsd:string |
| http://purl.uniprot.org/citations/21061439 | http://purl.uniprot.org/core/author | "Barker B.R."xsd:string |
| http://purl.uniprot.org/citations/21061439 | http://purl.uniprot.org/core/author | "Gillard G.O."xsd:string |
| http://purl.uniprot.org/citations/21061439 | http://purl.uniprot.org/core/author | "Gladstone M.N."xsd:string |
| http://purl.uniprot.org/citations/21061439 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21061439 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21061439 | http://purl.uniprot.org/core/pages | "3085-3096"xsd:string |
| http://purl.uniprot.org/citations/21061439 | http://purl.uniprot.org/core/title | "Critical role for IL-21 in both primary and memory anti-viral CD8+ T-cell responses."xsd:string |
| http://purl.uniprot.org/citations/21061439 | http://purl.uniprot.org/core/volume | "40"xsd:string |
| http://purl.uniprot.org/citations/21061439 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21061439 |
| http://purl.uniprot.org/citations/21061439 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21061439 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RP02-mappedCitation-21061439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21061439 |
| http://purl.uniprot.org/uniprot/#_E9QA82-mappedCitation-21061439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21061439 |
| http://purl.uniprot.org/uniprot/#_A2AP38-mappedCitation-21061439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21061439 |
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| http://purl.uniprot.org/uniprot/#_Q501M1-mappedCitation-21061439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21061439 |
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| http://purl.uniprot.org/uniprot/#_Q3TA82-mappedCitation-21061439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21061439 |
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| http://purl.uniprot.org/uniprot/#_Q60819-mappedCitation-21061439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21061439 |