http://purl.uniprot.org/citations/21063096 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/21063096 | http://www.w3.org/2000/01/rdf-schema#comment | "The serum- and glucocorticoid-regulated kinase (Sgk1) is essential for hormonal regulation of ENaC-mediated sodium transport and is involved in the transduction of growth-factor-dependent cell survival and proliferation. The identification of molecular partners for Sgk1 is crucial for the understanding of its mechanisms of action. We performed a yeast two-hybrid screening based on a human kidney cDNA library to identify molecular partners of Sgk1. As a result the screening revealed a specific interaction between Sgk1 and a 60 kDa Lysophospholipase (LysoLP). LysoLP is a poorly characterized enzyme that, based on sequence analysis, might possess lysophospholipase and asparaginase activities. We demonstrate that LysoLP has indeed a lysophospholipase activity and affects metabolic functions related to cell proliferation and regulation of membrane channels. Moreover we demonstrate in the Xenopus oocyte expression system that LysoLP downregulates basal and Sgk1-dependent ENaC activity. In conclusion LysoLP may represent a new player in the regulation of ENaC and Sgk1-dependent signaling."xsd:string |
http://purl.uniprot.org/citations/21063096 | http://purl.org/dc/terms/identifier | "doi:10.1159/000322326"xsd:string |
http://purl.uniprot.org/citations/21063096 | http://purl.uniprot.org/core/author | "Lang F."xsd:string |
http://purl.uniprot.org/citations/21063096 | http://purl.uniprot.org/core/author | "Corda D."xsd:string |
http://purl.uniprot.org/citations/21063096 | http://purl.uniprot.org/core/author | "Perrotti N."xsd:string |
http://purl.uniprot.org/citations/21063096 | http://purl.uniprot.org/core/author | "Mariggio S."xsd:string |
http://purl.uniprot.org/citations/21063096 | http://purl.uniprot.org/core/author | "Menniti M."xsd:string |
http://purl.uniprot.org/citations/21063096 | http://purl.uniprot.org/core/author | "Iuliano R."xsd:string |
http://purl.uniprot.org/citations/21063096 | http://purl.uniprot.org/core/author | "Nofziger C."xsd:string |
http://purl.uniprot.org/citations/21063096 | http://purl.uniprot.org/core/author | "Amato R."xsd:string |
http://purl.uniprot.org/citations/21063096 | http://purl.uniprot.org/core/author | "Alesutan I."xsd:string |
http://purl.uniprot.org/citations/21063096 | http://purl.uniprot.org/core/author | "Sopjani M."xsd:string |
http://purl.uniprot.org/citations/21063096 | http://purl.uniprot.org/core/author | "Foller M."xsd:string |
http://purl.uniprot.org/citations/21063096 | http://purl.uniprot.org/core/author | "Blazer-Yost B."xsd:string |
http://purl.uniprot.org/citations/21063096 | http://purl.uniprot.org/core/author | "Perri A.M."xsd:string |
http://purl.uniprot.org/citations/21063096 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
http://purl.uniprot.org/citations/21063096 | http://purl.uniprot.org/core/name | "Cell Physiol Biochem"xsd:string |
http://purl.uniprot.org/citations/21063096 | http://purl.uniprot.org/core/pages | "587-596"xsd:string |
http://purl.uniprot.org/citations/21063096 | http://purl.uniprot.org/core/title | "60kDa lysophospholipase, a new Sgk1 molecular partner involved in the regulation of ENaC."xsd:string |
http://purl.uniprot.org/citations/21063096 | http://purl.uniprot.org/core/volume | "26"xsd:string |
http://purl.uniprot.org/citations/21063096 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21063096 |
http://purl.uniprot.org/citations/21063096 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21063096 |
http://purl.uniprot.org/uniprot/#_G3V1Y8-mappedCitation-21063096 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21063096 |
http://purl.uniprot.org/uniprot/#_Q86U10-mappedCitation-21063096 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21063096 |