| http://purl.uniprot.org/citations/21064109 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21064109 | http://www.w3.org/2000/01/rdf-schema#comment | "Development of colorectal cancer (CRC) involves a series of genetic alterations with altered expression of proteins and cell signaling pathways. Here, we identified that galectin-4 (gal-4), a marker of differentiation, was down-regulated in CRC. The goal of this work was to determine the function of gal-4 in CRC. Toward this goal, the human colon biopsies and tissue microarrays containing a gradient of pathology were analyzed for gal-4 expression by immunohistochemistry. Cell proliferation, migration, motility, forced expression, knockdown, cell cycle and apoptosis assays were used to characterize gal-4 function. Immunohistochemistry identified that gal-4 expression was significantly down-regulated in adenomas and was essentially absent in invasive carcinomas. Forced expression of gal-4 in gal-4 -ve cells induced cell cycle arrest and retarded cell migration and motility. Further, gal-4 sensitized the cells to camptothecin-induced apoptosis. Gal-4 knockdown resulted in increased cell proliferation, migration and motility. Gal-4 was found to be associated with Wnt signaling proteins. Finally, gal-4 expression led to down-regulation of Wnt signaling target genes. This study demonstrates that loss of gal-4 is a common and specific event in CRC. This study also shows that gal-4 exhibits tumor suppressive effects in CRC cells in vitro. Through its ability to interact with and down-regulate the functions of Wnt signaling pathway, gal-4 reveals a new dimension in the control of the Wnt signaling pathway. Thus, gal-4 may prove to be an important molecule in understanding the biology of CRC."xsd:string |
| http://purl.uniprot.org/citations/21064109 | http://purl.org/dc/terms/identifier | "doi:10.1002/ijc.25750"xsd:string |
| http://purl.uniprot.org/citations/21064109 | http://purl.uniprot.org/core/author | "Rao U.S."xsd:string |
| http://purl.uniprot.org/citations/21064109 | http://purl.uniprot.org/core/author | "Rao P.S."xsd:string |
| http://purl.uniprot.org/citations/21064109 | http://purl.uniprot.org/core/author | "Satelli A."xsd:string |
| http://purl.uniprot.org/citations/21064109 | http://purl.uniprot.org/core/author | "Thirumala S."xsd:string |
| http://purl.uniprot.org/citations/21064109 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21064109 | http://purl.uniprot.org/core/name | "Int J Cancer"xsd:string |
| http://purl.uniprot.org/citations/21064109 | http://purl.uniprot.org/core/pages | "799-809"xsd:string |
| http://purl.uniprot.org/citations/21064109 | http://purl.uniprot.org/core/title | "Galectin-4 functions as a tumor suppressor of human colorectal cancer."xsd:string |
| http://purl.uniprot.org/citations/21064109 | http://purl.uniprot.org/core/volume | "129"xsd:string |
| http://purl.uniprot.org/citations/21064109 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21064109 |
| http://purl.uniprot.org/citations/21064109 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21064109 |
| http://purl.uniprot.org/uniprot/#_B4DKK5-mappedCitation-21064109 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21064109 |
| http://purl.uniprot.org/uniprot/#_B4DJR1-mappedCitation-21064109 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21064109 |
| http://purl.uniprot.org/uniprot/#_P56470-mappedCitation-21064109 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21064109 |
| http://purl.uniprot.org/uniprot/#_Q6FHZ4-mappedCitation-21064109 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21064109 |
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| http://purl.uniprot.org/uniprot/B4DKK5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21064109 |
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| http://purl.uniprot.org/uniprot/Q6FHZ4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21064109 |