http://purl.uniprot.org/citations/21068400 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/21068400 | http://www.w3.org/2000/01/rdf-schema#comment | "Various innate-like T cell subsets preferentially reside in specific epithelial tissues as the first line of defense. However, mechanisms regulating their tissue-specific development are poorly understood. Using the prototypical skin intraepithelial γδT cells (sIELs) as a model, we show in this study that a TCR-mediated selection plays an important role in promoting acquisition of a specific skin-homing property by fetal thymic sIEL precursors for their epidermal location, and the skin-homing potential is intrinsically programmed even before the selection. In addition, once localized in the skin, the sIEL precursors develop into sIELs without the requirement of further TCR-ligand interaction. These studies reveal that development of the tissue-specific lymphocytes is a hard-wired process that targets them to specific tissues for proper functions."xsd:string |
http://purl.uniprot.org/citations/21068400 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1002781"xsd:string |
http://purl.uniprot.org/citations/21068400 | http://purl.uniprot.org/core/author | "Jin Y."xsd:string |
http://purl.uniprot.org/citations/21068400 | http://purl.uniprot.org/core/author | "Kang J."xsd:string |
http://purl.uniprot.org/citations/21068400 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
http://purl.uniprot.org/citations/21068400 | http://purl.uniprot.org/core/author | "Xia M."xsd:string |
http://purl.uniprot.org/citations/21068400 | http://purl.uniprot.org/core/author | "Narayan K."xsd:string |
http://purl.uniprot.org/citations/21068400 | http://purl.uniprot.org/core/author | "Wiest D.L."xsd:string |
http://purl.uniprot.org/citations/21068400 | http://purl.uniprot.org/core/author | "Xiong N."xsd:string |
http://purl.uniprot.org/citations/21068400 | http://purl.uniprot.org/core/author | "Saylor C.M."xsd:string |
http://purl.uniprot.org/citations/21068400 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
http://purl.uniprot.org/citations/21068400 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
http://purl.uniprot.org/citations/21068400 | http://purl.uniprot.org/core/pages | "7156-7160"xsd:string |
http://purl.uniprot.org/citations/21068400 | http://purl.uniprot.org/core/title | "Cutting edge: Intrinsic programming of thymic gammadeltaT cells for specific peripheral tissue localization."xsd:string |
http://purl.uniprot.org/citations/21068400 | http://purl.uniprot.org/core/volume | "185"xsd:string |
http://purl.uniprot.org/citations/21068400 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21068400 |
http://purl.uniprot.org/citations/21068400 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21068400 |
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http://purl.uniprot.org/uniprot/#_P01887-mappedCitation-21068400 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21068400 |
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http://purl.uniprot.org/uniprot/Q9JL21 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21068400 |
http://purl.uniprot.org/uniprot/P01887 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21068400 |