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http://purl.uniprot.org/citations/21068400http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21068400http://www.w3.org/2000/01/rdf-schema#comment"Various innate-like T cell subsets preferentially reside in specific epithelial tissues as the first line of defense. However, mechanisms regulating their tissue-specific development are poorly understood. Using the prototypical skin intraepithelial γδT cells (sIELs) as a model, we show in this study that a TCR-mediated selection plays an important role in promoting acquisition of a specific skin-homing property by fetal thymic sIEL precursors for their epidermal location, and the skin-homing potential is intrinsically programmed even before the selection. In addition, once localized in the skin, the sIEL precursors develop into sIELs without the requirement of further TCR-ligand interaction. These studies reveal that development of the tissue-specific lymphocytes is a hard-wired process that targets them to specific tissues for proper functions."xsd:string
http://purl.uniprot.org/citations/21068400http://purl.org/dc/terms/identifier"doi:10.4049/jimmunol.1002781"xsd:string
http://purl.uniprot.org/citations/21068400http://purl.uniprot.org/core/author"Jin Y."xsd:string
http://purl.uniprot.org/citations/21068400http://purl.uniprot.org/core/author"Kang J."xsd:string
http://purl.uniprot.org/citations/21068400http://purl.uniprot.org/core/author"Wang Y."xsd:string
http://purl.uniprot.org/citations/21068400http://purl.uniprot.org/core/author"Xia M."xsd:string
http://purl.uniprot.org/citations/21068400http://purl.uniprot.org/core/author"Narayan K."xsd:string
http://purl.uniprot.org/citations/21068400http://purl.uniprot.org/core/author"Wiest D.L."xsd:string
http://purl.uniprot.org/citations/21068400http://purl.uniprot.org/core/author"Xiong N."xsd:string
http://purl.uniprot.org/citations/21068400http://purl.uniprot.org/core/author"Saylor C.M."xsd:string
http://purl.uniprot.org/citations/21068400http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/21068400http://purl.uniprot.org/core/name"J Immunol"xsd:string
http://purl.uniprot.org/citations/21068400http://purl.uniprot.org/core/pages"7156-7160"xsd:string
http://purl.uniprot.org/citations/21068400http://purl.uniprot.org/core/title"Cutting edge: Intrinsic programming of thymic gammadeltaT cells for specific peripheral tissue localization."xsd:string
http://purl.uniprot.org/citations/21068400http://purl.uniprot.org/core/volume"185"xsd:string
http://purl.uniprot.org/citations/21068400http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/21068400
http://purl.uniprot.org/citations/21068400http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/21068400
http://purl.uniprot.org/uniprot/#_A7TZE6-mappedCitation-21068400http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21068400
http://purl.uniprot.org/uniprot/#_P01887-mappedCitation-21068400http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21068400
http://purl.uniprot.org/uniprot/#_Q3U679-mappedCitation-21068400http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21068400
http://purl.uniprot.org/uniprot/#_Q9JL21-mappedCitation-21068400http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21068400
http://purl.uniprot.org/uniprot/#_Q9D239-mappedCitation-21068400http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/21068400
http://purl.uniprot.org/uniprot/Q9JL21http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/21068400
http://purl.uniprot.org/uniprot/P01887http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/21068400