DESCRIBE <http://purl.uniprot.org/citations/21069851>

Subject	Predicate	Object
http://purl.uniprot.org/citations/21069851	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/21069851	http://www.w3.org/2000/01/rdf-schema#comment	" Background Pituitary tumor transforming gene (PTTG1) is overexpressed in many types of human cancers and is involved in late-stage tumor progression. The role of PTTG1 in initiating tumorigenesis is unclear. Methods PTTG1 expression was assessed in precancerous lesions and squamous cell carcinomas of the oral cavity (OSCC). The association between the protein expression and clinicopathologic parameters was analyzed. The expression level of PTTG1 upon carcinogen treatment was also investigated. Results PTTG1 was overexpressed in both precancerous lesions and OSCC. The expression of PTTG1 was associated with carcinogen exposure in vivo and in vitro. PTTG1 overexpression was an independent factor for oral cancer development in precancerous lesions. Conclusions This study provides the first evidence that PTTG1 is involved in the early stages of oral tumorigenesis. Carcinogen exposure may cause the initial induction of PTTG1 expression in oral precancerous lesions. PTTG1 overexpression is a potential prognosticator for malignant progression of oral precancerous lesions."xsd:string
http://purl.uniprot.org/citations/21069851	http://purl.org/dc/terms/identifier	"doi:10.1002/hed.21531"xsd:string
http://purl.uniprot.org/citations/21069851	http://purl.uniprot.org/core/author	"Lin J.J."xsd:string
http://purl.uniprot.org/citations/21069851	http://purl.uniprot.org/core/author	"Yu C.H."xsd:string
http://purl.uniprot.org/citations/21069851	http://purl.uniprot.org/core/author	"Chang L.C."xsd:string
http://purl.uniprot.org/citations/21069851	http://purl.uniprot.org/core/author	"Hsu Y.H."xsd:string
http://purl.uniprot.org/citations/21069851	http://purl.uniprot.org/core/author	"Chiang C.P."xsd:string
http://purl.uniprot.org/citations/21069851	http://purl.uniprot.org/core/author	"Liao L.J."xsd:string
http://purl.uniprot.org/citations/21069851	http://purl.uniprot.org/core/author	"Jhan J.R."xsd:string
http://purl.uniprot.org/citations/21069851	http://purl.uniprot.org/core/author	"Lou P.J."xsd:string
http://purl.uniprot.org/citations/21069851	http://purl.uniprot.org/core/date	"2011"xsd:gYear
http://purl.uniprot.org/citations/21069851	http://purl.uniprot.org/core/name	"Head Neck"xsd:string
http://purl.uniprot.org/citations/21069851	http://purl.uniprot.org/core/pages	"719-726"xsd:string
http://purl.uniprot.org/citations/21069851	http://purl.uniprot.org/core/title	"Association of pituitary tumor transforming gene expression with early oral tumorigenesis and malignant progression of precancerous lesions."xsd:string
http://purl.uniprot.org/citations/21069851	http://purl.uniprot.org/core/volume	"33"xsd:string
http://purl.uniprot.org/citations/21069851	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/21069851
http://purl.uniprot.org/citations/21069851	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/21069851
http://purl.uniprot.org/uniprot/#_C4TNW4-mappedCitation-21069851	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/21069851
http://purl.uniprot.org/uniprot/#_O95997-mappedCitation-21069851	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/21069851
http://purl.uniprot.org/uniprot/#_O95211-mappedCitation-21069851	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/21069851
http://purl.uniprot.org/uniprot/#_Q2VPE7-mappedCitation-21069851	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/21069851
http://purl.uniprot.org/uniprot/#_Q6IAL9-mappedCitation-21069851	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/21069851
http://purl.uniprot.org/uniprot/O95211	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/21069851
http://purl.uniprot.org/uniprot/C4TNW4	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/21069851