| http://purl.uniprot.org/citations/21070606 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21070606 | http://www.w3.org/2000/01/rdf-schema#comment | "In murine models, the adoptive transfer of CD4(+) /CD25(+) regulatory T cells (T(regs) ) inhibited graft-versus-host disease (GvHD). Previous work has indicated a critical role for the adhesion molecule L-selectin (CD62L) in the function of T(regs) in preventing GvHD. Here we examined the capacity of naive wild-type (WT), CD62L(-/-) and ex vivo expanded CD62L(Lo) T(regs) to inhibit acute GvHD. Surprisingly, we found that CD62L(-/-) T(regs) were potent suppressors of GvHD, whereas CD62L(Lo) T(regs) were unable to inhibit disease despite being functionally competent to suppress allo T cell responses in vitro. Concomitant with improved outcomes, WT and CD62L(-/-) T(regs) significantly reduced liver pathology and systemic pro-inflammatory cytokine production, although CD62L(-/-) T(regs) were less effective in reducing lung pathology. While accumulation of CD62L(-/-) T(regs) in GvHD target organs was equivalent to WT T(regs) , CD62L(-/-) T(regs) did not migrate as well as WT T(regs) to peripheral lymph nodes (PLNs) over the first 2 weeks posttransplantation. This work demonstrated that CD62L was dispensable for T(reg) -mediated protection from GvHD."xsd:string |
| http://purl.uniprot.org/citations/21070606 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1600-6143.2010.03319.x"xsd:string |
| http://purl.uniprot.org/citations/21070606 | http://purl.uniprot.org/core/author | "Wan Y."xsd:string |
| http://purl.uniprot.org/citations/21070606 | http://purl.uniprot.org/core/author | "Tedder T.F."xsd:string |
| http://purl.uniprot.org/citations/21070606 | http://purl.uniprot.org/core/author | "West M.L."xsd:string |
| http://purl.uniprot.org/citations/21070606 | http://purl.uniprot.org/core/author | "Fulton L.M."xsd:string |
| http://purl.uniprot.org/citations/21070606 | http://purl.uniprot.org/core/author | "Blazar B.R."xsd:string |
| http://purl.uniprot.org/citations/21070606 | http://purl.uniprot.org/core/author | "Panoskaltsis-Mortari A."xsd:string |
| http://purl.uniprot.org/citations/21070606 | http://purl.uniprot.org/core/author | "Burgents J.E."xsd:string |
| http://purl.uniprot.org/citations/21070606 | http://purl.uniprot.org/core/author | "Carlson M.J."xsd:string |
| http://purl.uniprot.org/citations/21070606 | http://purl.uniprot.org/core/author | "Serody J.S."xsd:string |
| http://purl.uniprot.org/citations/21070606 | http://purl.uniprot.org/core/author | "Coghill J.M."xsd:string |
| http://purl.uniprot.org/citations/21070606 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21070606 | http://purl.uniprot.org/core/name | "Am J Transplant"xsd:string |
| http://purl.uniprot.org/citations/21070606 | http://purl.uniprot.org/core/pages | "2596-2603"xsd:string |
| http://purl.uniprot.org/citations/21070606 | http://purl.uniprot.org/core/title | "L-selectin is dispensable for T regulatory cell function postallogeneic bone marrow transplantation."xsd:string |
| http://purl.uniprot.org/citations/21070606 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/21070606 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21070606 |
| http://purl.uniprot.org/citations/21070606 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21070606 |
| http://purl.uniprot.org/uniprot/#_B1B506-mappedCitation-21070606 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21070606 |
| http://purl.uniprot.org/uniprot/#_B1B507-mappedCitation-21070606 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21070606 |
| http://purl.uniprot.org/uniprot/#_Q3UV83-mappedCitation-21070606 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21070606 |
| http://purl.uniprot.org/uniprot/#_P18337-mappedCitation-21070606 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21070606 |
| http://purl.uniprot.org/uniprot/#_Q3TCF3-mappedCitation-21070606 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21070606 |