| http://purl.uniprot.org/citations/21071176 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21071176 | http://www.w3.org/2000/01/rdf-schema#comment | "Antiepileptic drugs including lamotrigine (LTG) and carbamazepine (CBZ) are among the most common causes of cutaneous adverse reactions (cADRs). Human leukocyte antigen (HLA)-B*1502 has been strongly associated with CBZ-induced Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). To investigate this relationship, we performed high-resolution HLA genotyping on LTG-tolerant controls, healthy volunteers, and patients affected by LTG-induced cADRs, ranging from maculopapular exanthema (MPE) to SJS/TEN. Patients with LTG-induced cADRs (n=25, including three with SJS/TEN and 22 with MPE), 21 LTG-tolerant controls, and 71 healthy volunteers were enrolled. The differences in the starting dosage of LTG among the SJS/TEN, MPE, and LTG-tolerant control groups were not statistically significant. HLA-B*1502 frequency was 33.3% (1/3; LTG-induced SJS/TEN group), 9.1% (2/22; LTG-induced MPE group), 4.8% (1/21; LTG-tolerant group), and 8.5% (6/71; healthy volunteers). There was no significant difference in the frequency of subjects with the HLA-B*1502 allele between the SJS/TEN group and LTG-tolerant group (p=0.239, OR=10.0, 95% CI 0.44-228.7), and healthy volunteers (p=0.26, OR=5.42, 95% CI 0.43-68.8), MPE and LTG-tolerant groups (p=1.0, OR=1.08, 95% CI 0.20-5.8), and healthy volunteers (p=1.0, OR=2.0, 95% CI 0.17-23.9). None of the HLA alleles detected were associated with LTG-induced cADRs. In conclusion, HLA-B*1502 and other HLA alleles are not directly associated with LTG-induced MPE. The possibility that HLA-B*1502 is associated with an increased risk of LTG-induced SJS/TEN could not be excluded."xsd:string |
| http://purl.uniprot.org/citations/21071176 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.eplepsyres.2010.10.006"xsd:string |
| http://purl.uniprot.org/citations/21071176 | http://purl.uniprot.org/core/author | "Zhou D."xsd:string |
| http://purl.uniprot.org/citations/21071176 | http://purl.uniprot.org/core/author | "Yan B."xsd:string |
| http://purl.uniprot.org/citations/21071176 | http://purl.uniprot.org/core/author | "Hu F.Y."xsd:string |
| http://purl.uniprot.org/citations/21071176 | http://purl.uniprot.org/core/author | "Wu X.T."xsd:string |
| http://purl.uniprot.org/citations/21071176 | http://purl.uniprot.org/core/author | "Stefan H."xsd:string |
| http://purl.uniprot.org/citations/21071176 | http://purl.uniprot.org/core/author | "An D.M."xsd:string |
| http://purl.uniprot.org/citations/21071176 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21071176 | http://purl.uniprot.org/core/name | "Epilepsy Res"xsd:string |
| http://purl.uniprot.org/citations/21071176 | http://purl.uniprot.org/core/pages | "226-230"xsd:string |
| http://purl.uniprot.org/citations/21071176 | http://purl.uniprot.org/core/title | "Association study of lamotrigine-induced cutaneous adverse reactions and HLA-B*1502 in a Han Chinese population."xsd:string |
| http://purl.uniprot.org/citations/21071176 | http://purl.uniprot.org/core/volume | "92"xsd:string |
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