| http://purl.uniprot.org/citations/21071223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21071223 | http://www.w3.org/2000/01/rdf-schema#comment | "From high throughput screening, we discovered compound 1, the prototype for a series of disubstituted thiophene inhibitors of JNK which is selective towards closely related MAP kinases p38 and Erk2. Herein we describe the evolution of these compounds to a novel class of thiophene and thiazole JNK inhibitors that retain favorable solubility, permeability, and P-gp properties for development as CNS agents for treatment of neurodegeneration. Compound 61 demonstrated JNK3 IC(50)=77 nM and retained the excellent broad kinase selectivity observed for the series."xsd:string |
| http://purl.uniprot.org/citations/21071223 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bmcl.2010.10.066"xsd:string |
| http://purl.uniprot.org/citations/21071223 | http://purl.uniprot.org/core/author | "Fang L."xsd:string |
| http://purl.uniprot.org/citations/21071223 | http://purl.uniprot.org/core/author | "Pan H."xsd:string |
| http://purl.uniprot.org/citations/21071223 | http://purl.uniprot.org/core/author | "Powell K."xsd:string |
| http://purl.uniprot.org/citations/21071223 | http://purl.uniprot.org/core/author | "Wu J."xsd:string |
| http://purl.uniprot.org/citations/21071223 | http://purl.uniprot.org/core/author | "Yao N."xsd:string |
| http://purl.uniprot.org/citations/21071223 | http://purl.uniprot.org/core/author | "Griswold-Prenner I."xsd:string |
| http://purl.uniprot.org/citations/21071223 | http://purl.uniprot.org/core/author | "Ren Z."xsd:string |
| http://purl.uniprot.org/citations/21071223 | http://purl.uniprot.org/core/author | "Bowers S."xsd:string |
| http://purl.uniprot.org/citations/21071223 | http://purl.uniprot.org/core/author | "Bard F."xsd:string |
| http://purl.uniprot.org/citations/21071223 | http://purl.uniprot.org/core/author | "Sham H.L."xsd:string |
| http://purl.uniprot.org/citations/21071223 | http://purl.uniprot.org/core/author | "Artis D.R."xsd:string |
| http://purl.uniprot.org/citations/21071223 | http://purl.uniprot.org/core/author | "Toth G."xsd:string |
| http://purl.uniprot.org/citations/21071223 | http://purl.uniprot.org/core/author | "Yednock T.A."xsd:string |
| http://purl.uniprot.org/citations/21071223 | http://purl.uniprot.org/core/author | "Quinn K."xsd:string |
| http://purl.uniprot.org/citations/21071223 | http://purl.uniprot.org/core/author | "Sauer J.M."xsd:string |
| http://purl.uniprot.org/citations/21071223 | http://purl.uniprot.org/core/author | "Brogley L."xsd:string |
| http://purl.uniprot.org/citations/21071223 | http://purl.uniprot.org/core/author | "Hom R.K."xsd:string |
| http://purl.uniprot.org/citations/21071223 | http://purl.uniprot.org/core/author | "Probst G.D."xsd:string |
| http://purl.uniprot.org/citations/21071223 | http://purl.uniprot.org/core/author | "Konradi A.W."xsd:string |
| http://purl.uniprot.org/citations/21071223 | http://purl.uniprot.org/core/author | "Sealy J.M."xsd:string |
| http://purl.uniprot.org/citations/21071223 | http://purl.uniprot.org/core/author | "Truong A.P."xsd:string |
| http://purl.uniprot.org/citations/21071223 | http://purl.uniprot.org/core/author | "Neitz R.J."xsd:string |