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| http://purl.uniprot.org/citations/21074460 | http://www.w3.org/2000/01/rdf-schema#comment | "Immune tolerance against enteric commensal bacteria is important for preventing intestinal inflammation. Deletion of phosphoinositide-dependent protein kinase 1 (Pdk1) in T cells via Cd4-Cre induced chronic inflammation of the intestine despite the importance of PDK1 in T cell activation. Analysis of colonic intraepithelial lymphocytes of PDK1-deficient mice revealed markedly increased CD8α(+) T cell receptor (TCR)γδ(+) T cells, including an interleukin-17 (IL-17)-expressing population. TCRγδ(+) T cells were responsible for the inflammatory colitis as shown by the fact that deletion of Tcrd abolished spontaneous colitis in the PDK1-deficient mice. This dysregulation of intestinal TCRγδ(+) T cells was attributable to a reduction in the number and functional capacity of PDK1-deficient T regulatory (Treg) cells. Adoptive transfer of wild-type Treg cells abrogated the spontaneous activation and proliferation of intestinal TCRγδ(+) T cells observed in PDK1-deficient mice and prevented the development of colitis. Therefore, suppression of intestinal TCRγδ(+) T cells by Treg cells maintains enteric immune tolerance."xsd:string |
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| http://purl.uniprot.org/citations/21074460 | http://purl.uniprot.org/core/author | "Ghosh S."xsd:string |
| http://purl.uniprot.org/citations/21074460 | http://purl.uniprot.org/core/author | "Hao L."xsd:string |
| http://purl.uniprot.org/citations/21074460 | http://purl.uniprot.org/core/author | "Park S.G."xsd:string |
| http://purl.uniprot.org/citations/21074460 | http://purl.uniprot.org/core/author | "Long M."xsd:string |
| http://purl.uniprot.org/citations/21074460 | http://purl.uniprot.org/core/author | "Hayden M.S."xsd:string |
| http://purl.uniprot.org/citations/21074460 | http://purl.uniprot.org/core/author | "Mathur R."xsd:string |
| http://purl.uniprot.org/citations/21074460 | http://purl.uniprot.org/core/author | "Hosh N."xsd:string |
| http://purl.uniprot.org/citations/21074460 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21074460 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
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| http://purl.uniprot.org/citations/21074460 | http://purl.uniprot.org/core/title | "T regulatory cells maintain intestinal homeostasis by suppressing gammadelta T cells."xsd:string |
| http://purl.uniprot.org/citations/21074460 | http://purl.uniprot.org/core/volume | "33"xsd:string |
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