| http://purl.uniprot.org/citations/21077277 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21077277 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21077277 | http://www.w3.org/2000/01/rdf-schema#comment | "Human colonic epithelial cells express T helper type 1 (Th1)-associated chemoattractants, yet little is known about the production of Th2-associated chemoattractants. CCL11/eotaxin-1, CCL24/eotaxin-2 and CCL26/eotaxin-3 are known to attract CCR3-expressing, Th2-polarized lymphocytes. We studied constitutive and inflammation-induced expression and production of CCR3 together with its ligands in the colon and peripheral blood of patients with inflammatory bowel disease (IBD) by flow cytometry, reverse transcription–polymerase chain reaction (RT–PCR) and enzyme-linked immunosorbent assay (ELISA). We further defined the regulated expression of these chemokines by RT–PCR and ELISA using cultured human epithelial cell lines. A higher fraction of peripheral T lymphocytes were found to be positive for CCR3 in patients with ulcerative colitis (UC) compared to Crohn’s disease (CD), while almost no CCR3(+) T cells were found in normal controls (NC). Similarly, higher and more frequent expression of CCR3 was observed in colonic biopsies from patients with UC, regardless of the disease activity, when compared to CD or NCs. Serum CCL11/eotaxin-1 was increased significantly in UC (306 ± 87 pg/ml) and less so in CD (257 ± 43 pg/ml), whereas CCL24/eotaxin-2, and CCL26/eotaxin-3 were increased only in UC. Colonic expression of the three chemokines was minimal in NCs but high in inflammatory bowel diseases (especially UC) and was independent of disease activity. Th2, and to a lesser extent Th1, cytokines were able to induce expression and production of all three eotaxins from colonic epithelial cells in culture. CCR3 and ligands over-expression would appear to be a characteristic of UC. The production of CCR3 ligands by human colonic epithelial cells suggests further that epithelium can play a role in modulating pathological T cell-mediated mucosal inflammation."xsd:string |
| http://purl.uniprot.org/citations/21077277 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2249.2010.04248.x"xsd:string |
| http://purl.uniprot.org/citations/21077277 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1365-2249.2010.04248.x"xsd:string |
| http://purl.uniprot.org/citations/21077277 | http://purl.uniprot.org/core/author | "Bourikas L."xsd:string |
| http://purl.uniprot.org/citations/21077277 | http://purl.uniprot.org/core/author | "Bourikas L."xsd:string |
| http://purl.uniprot.org/citations/21077277 | http://purl.uniprot.org/core/author | "Drygiannakis I."xsd:string |
| http://purl.uniprot.org/citations/21077277 | http://purl.uniprot.org/core/author | "Drygiannakis I."xsd:string |
| http://purl.uniprot.org/citations/21077277 | http://purl.uniprot.org/core/author | "Kolios G."xsd:string |
| http://purl.uniprot.org/citations/21077277 | http://purl.uniprot.org/core/author | "Kolios G."xsd:string |
| http://purl.uniprot.org/citations/21077277 | http://purl.uniprot.org/core/author | "Kouroumalis E."xsd:string |
| http://purl.uniprot.org/citations/21077277 | http://purl.uniprot.org/core/author | "Kouroumalis E."xsd:string |
| http://purl.uniprot.org/citations/21077277 | http://purl.uniprot.org/core/author | "Koutroubakis I."xsd:string |
| http://purl.uniprot.org/citations/21077277 | http://purl.uniprot.org/core/author | "Koutroubakis I."xsd:string |
| http://purl.uniprot.org/citations/21077277 | http://purl.uniprot.org/core/author | "Manousou P."xsd:string |
| http://purl.uniprot.org/citations/21077277 | http://purl.uniprot.org/core/author | "Manousou P."xsd:string |
| http://purl.uniprot.org/citations/21077277 | http://purl.uniprot.org/core/author | "Papadaki H.A."xsd:string |
| http://purl.uniprot.org/citations/21077277 | http://purl.uniprot.org/core/author | "Papadaki H.A."xsd:string |
| http://purl.uniprot.org/citations/21077277 | http://purl.uniprot.org/core/author | "Pyrovolaki K."xsd:string |
| http://purl.uniprot.org/citations/21077277 | http://purl.uniprot.org/core/author | "Pyrovolaki K."xsd:string |
| http://purl.uniprot.org/citations/21077277 | http://purl.uniprot.org/core/author | "Valatas V."xsd:string |
| http://purl.uniprot.org/citations/21077277 | http://purl.uniprot.org/core/author | "Valatas V."xsd:string |
| http://purl.uniprot.org/citations/21077277 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21077277 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |