| http://purl.uniprot.org/citations/21078964 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21078964 | http://www.w3.org/2000/01/rdf-schema#comment | "Inositol pyrophosphates have been implicated in numerous biological processes. Inositol hexakisphosphate kinase-2 (IP6K2), which generates the inositol pyrophosphate, diphosphoinositol pentakisphosphate (IP7), influences apoptotic cell death. The tumor suppressor p53 responds to genotoxic stress by engaging a transcriptional program leading to cell-cycle arrest or apoptosis. We demonstrate that IP6K2 is required for p53-mediated apoptosis and modulates the outcome of the p53 response. Gene disruption of IP6K2 in colorectal cancer cells selectively impairs p53-mediated apoptosis, instead favoring cell-cycle arrest. IP6K2 acts by binding directly to p53 and decreasing expression of proarrest gene targets such as the cyclin-dependent kinase inhibitor p21."xsd:string |
| http://purl.uniprot.org/citations/21078964 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1015671107"xsd:string |
| http://purl.uniprot.org/citations/21078964 | http://purl.uniprot.org/core/author | "Kim S."xsd:string |
| http://purl.uniprot.org/citations/21078964 | http://purl.uniprot.org/core/author | "Chakraborty A."xsd:string |
| http://purl.uniprot.org/citations/21078964 | http://purl.uniprot.org/core/author | "Snyder S.H."xsd:string |
| http://purl.uniprot.org/citations/21078964 | http://purl.uniprot.org/core/author | "Juluri K.R."xsd:string |
| http://purl.uniprot.org/citations/21078964 | http://purl.uniprot.org/core/author | "Snowman A.M."xsd:string |
| http://purl.uniprot.org/citations/21078964 | http://purl.uniprot.org/core/author | "Werner J.K. Jr."xsd:string |
| http://purl.uniprot.org/citations/21078964 | http://purl.uniprot.org/core/author | "Heletz S."xsd:string |
| http://purl.uniprot.org/citations/21078964 | http://purl.uniprot.org/core/author | "Koldobskiy M.A."xsd:string |
| http://purl.uniprot.org/citations/21078964 | http://purl.uniprot.org/core/author | "Vandiver M.S."xsd:string |
| http://purl.uniprot.org/citations/21078964 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21078964 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/21078964 | http://purl.uniprot.org/core/pages | "20947-20951"xsd:string |
| http://purl.uniprot.org/citations/21078964 | http://purl.uniprot.org/core/title | "p53-mediated apoptosis requires inositol hexakisphosphate kinase-2."xsd:string |
| http://purl.uniprot.org/citations/21078964 | http://purl.uniprot.org/core/volume | "107"xsd:string |
| http://purl.uniprot.org/citations/21078964 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21078964 |
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