| http://purl.uniprot.org/citations/21079652 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21079652 | http://www.w3.org/2000/01/rdf-schema#comment | "The SWI/SNF chromatin-remodeling complexes utilize energy from ATP hydrolysis to reposition nucleosomes and regulate the expression of human genes. Here, we studied the roles of human Brahma (hBrm) and Brahma-related gene 1 (Brg1), the ATPase subunits of the SWI/SNF complexes, in regulating human genes. Our results indicate that both hBrm and Brg1 interact with Signal transducer and activator of transcription (Stat) 1 in vitro. However, Stat1 in its native form only recruits hBrm to IFNγ-activated sequences (GAS) of individual genes; by contrast, in a stress-induced phosphorylated form, Stat1 mainly binds to Brg1. Under basal conditions, hBrm is recruited by native Stat1 to the GAS and exists in a mSin3/HDAC co-repressor complex on the hsp90α gene, which shows a compact chromatin structure. Upon heat-shock, hBrm is acetylated by p300 and dissociates from the co-repressor complex, which the phosphorylated Stat1 is increased, and binds and recruits Brg1 to the GAS, leading to elevated induction of the gene. This hBrm/Brg1 switch also occurs at the GAS of all of the three examined immune genes in heat-shocked cells; however, this switch only occurs in specific cell types upon exposure to IFNγ. Regardless of the stimulus, the hBrm/Brg1 switch at the GAS elicits an increase in gene activity. Our data are consistent with the hypothesis that the hBrm/Brg1 switch is an indicator of the responsiveness of a gene to heat-shock or IFNγ stimulation and may represent an "on-off switch" of gene expression in vivo."xsd:string |
| http://purl.uniprot.org/citations/21079652 | http://purl.org/dc/terms/identifier | "doi:10.1038/cr.2010.155"xsd:string |
| http://purl.uniprot.org/citations/21079652 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/21079652 | http://purl.uniprot.org/core/author | "Yan L."xsd:string |
| http://purl.uniprot.org/citations/21079652 | http://purl.uniprot.org/core/author | "Zhang Y.'"xsd:string |
| http://purl.uniprot.org/citations/21079652 | http://purl.uniprot.org/core/author | "Zhang Y.J."xsd:string |
| http://purl.uniprot.org/citations/21079652 | http://purl.uniprot.org/core/author | "Zhong X."xsd:string |
| http://purl.uniprot.org/citations/21079652 | http://purl.uniprot.org/core/author | "Dai H."xsd:string |
| http://purl.uniprot.org/citations/21079652 | http://purl.uniprot.org/core/author | "Wu N.H."xsd:string |
| http://purl.uniprot.org/citations/21079652 | http://purl.uniprot.org/core/author | "Shen Y.F."xsd:string |
| http://purl.uniprot.org/citations/21079652 | http://purl.uniprot.org/core/author | "Cheng M.B."xsd:string |
| http://purl.uniprot.org/citations/21079652 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21079652 | http://purl.uniprot.org/core/name | "Cell Res"xsd:string |
| http://purl.uniprot.org/citations/21079652 | http://purl.uniprot.org/core/pages | "1345-1360"xsd:string |
| http://purl.uniprot.org/citations/21079652 | http://purl.uniprot.org/core/title | "A switch from hBrm to Brg1 at IFNgamma-activated sequences mediates the activation of human genes."xsd:string |
| http://purl.uniprot.org/citations/21079652 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/21079652 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21079652 |
| http://purl.uniprot.org/citations/21079652 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21079652 |
| http://purl.uniprot.org/uniprot/#_A7E2E1-mappedCitation-21079652 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21079652 |
| http://purl.uniprot.org/uniprot/#_A5D6X0-mappedCitation-21079652 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21079652 |
| http://purl.uniprot.org/uniprot/#_B3KNW7-mappedCitation-21079652 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21079652 |
| http://purl.uniprot.org/uniprot/#_B4DK35-mappedCitation-21079652 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21079652 |
| http://purl.uniprot.org/uniprot/#_B4DSI8-mappedCitation-21079652 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21079652 |
| http://purl.uniprot.org/uniprot/#_B4DSC8-mappedCitation-21079652 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21079652 |