| http://purl.uniprot.org/citations/21079758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21079758 | http://www.w3.org/2000/01/rdf-schema#comment | "Proteins function by interacting with other molecules, where both native and nonnative interactions play important roles. Native interactions contribute to the stability and specificity of a complex, whereas nonnative interactions mainly perturb the binding kinetics. For intrinsically disordered proteins (IDPs), which do not adopt rigid structures when being free in solution, the role of nonnative interactions may be more prominent in binding processes due to their high flexibilities. In this work, we investigated the effect of nonnative hydrophobic interactions on the coupled folding and binding processes of IDPs and its interplay with chain flexibility by conducting molecular dynamics simulations. Our results showed that the free-energy profiles became rugged, and intermediate states occurred when nonnative hydrophobic interactions were introduced. The binding rate was initially accelerated and subsequently dramatically decreased as the strength of the nonnative hydrophobic interactions increased. Both thermodynamic and kinetic analysis showed that disordered systems were more readily affected by nonnative interactions than ordered systems. Furthermore, it was demonstrated that the kinetic advantage of IDPs ("fly-casting" mechanism) was enhanced by nonnative hydrophobic interactions. The relationship between chain flexibility and protein aggregation is also discussed."xsd:string |
| http://purl.uniprot.org/citations/21079758 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0015375"xsd:string |
| http://purl.uniprot.org/citations/21079758 | http://purl.uniprot.org/core/author | "Huang Y."xsd:string |
| http://purl.uniprot.org/citations/21079758 | http://purl.uniprot.org/core/author | "Liu Z."xsd:string |
| http://purl.uniprot.org/citations/21079758 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21079758 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/21079758 | http://purl.uniprot.org/core/pages | "e15375"xsd:string |
| http://purl.uniprot.org/citations/21079758 | http://purl.uniprot.org/core/title | "Nonnative interactions in coupled folding and binding processes of intrinsically disordered proteins."xsd:string |
| http://purl.uniprot.org/citations/21079758 | http://purl.uniprot.org/core/volume | "5"xsd:string |
| http://purl.uniprot.org/citations/21079758 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21079758 |
| http://purl.uniprot.org/citations/21079758 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21079758 |
| http://purl.uniprot.org/uniprot/#_B5A210-mappedCitation-21079758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21079758 |
| http://purl.uniprot.org/uniprot/#_B5A211-mappedCitation-21079758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21079758 |
| http://purl.uniprot.org/uniprot/#_B5A212-mappedCitation-21079758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21079758 |
| http://purl.uniprot.org/uniprot/#_B5A213-mappedCitation-21079758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21079758 |
| http://purl.uniprot.org/uniprot/#_B5A214-mappedCitation-21079758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21079758 |
| http://purl.uniprot.org/uniprot/#_B5A215-mappedCitation-21079758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21079758 |
| http://purl.uniprot.org/uniprot/#_B5A216-mappedCitation-21079758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21079758 |
| http://purl.uniprot.org/uniprot/#_B5A217-mappedCitation-21079758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21079758 |
| http://purl.uniprot.org/uniprot/#_B5A218-mappedCitation-21079758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21079758 |
| http://purl.uniprot.org/uniprot/#_B5A219-mappedCitation-21079758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21079758 |
| http://purl.uniprot.org/uniprot/#_B5A220-mappedCitation-21079758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21079758 |
| http://purl.uniprot.org/uniprot/#_B5A221-mappedCitation-21079758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21079758 |
| http://purl.uniprot.org/uniprot/#_B5A222-mappedCitation-21079758 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21079758 |