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| http://purl.uniprot.org/citations/21084666 | http://www.w3.org/2000/01/rdf-schema#comment | "We recently reported that TNFR-associated factor (TRAF)3, a ubiquitously expressed adaptor protein, promotes mature B cell apoptosis. However, the specific function of TRAF3 in T cells has remained unclear. In this article, we report the generation and characterization of T cell-specific TRAF3(-/-) mice, in which the traf3 gene was deleted from thymocytes and T cells. Ablation of TRAF3 in the T cell lineage did not affect CD4 or CD8 T cell populations in secondary lymphoid organs or the numbers or proportions of CD4(+),CD8(+) or double-positive or double-negative thymocytes, except that the T cell-specific TRAF3(-/-) mice had a 2-fold increase in FoxP3(+) T cells. In striking contrast to mice lacking TRAF3 in B cells, the T cell TRAF3-deficient mice exhibited defective IgG1 responses to a T-dependent Ag, as well as impaired T cell-mediated immunity to infection with Listeria monocytogenes. Surprisingly, we found that TRAF3 was recruited to the TCR/CD28 signaling complex upon costimulation and that TCR/CD28-mediated proximal and distal signaling events were compromised by TRAF3 deficiency. These findings provide insights into the roles played by TRAF3 in T cell activation and T cell-mediated immunity."xsd:string |
| http://purl.uniprot.org/citations/21084666 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1000290"xsd:string |
| http://purl.uniprot.org/citations/21084666 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/21084666 | http://purl.uniprot.org/core/author | "Xie P."xsd:string |
| http://purl.uniprot.org/citations/21084666 | http://purl.uniprot.org/core/author | "Bishop G.A."xsd:string |
| http://purl.uniprot.org/citations/21084666 | http://purl.uniprot.org/core/author | "Stunz L.L."xsd:string |
| http://purl.uniprot.org/citations/21084666 | http://purl.uniprot.org/core/author | "Kraus Z.J."xsd:string |
| http://purl.uniprot.org/citations/21084666 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21084666 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21084666 | http://purl.uniprot.org/core/pages | "143-155"xsd:string |
| http://purl.uniprot.org/citations/21084666 | http://purl.uniprot.org/core/title | "TNF receptor-associated factor 3 is required for T cell-mediated immunity and TCR/CD28 signaling."xsd:string |
| http://purl.uniprot.org/citations/21084666 | http://purl.uniprot.org/core/volume | "186"xsd:string |
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