| http://purl.uniprot.org/citations/21087601 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21087601 | http://www.w3.org/2000/01/rdf-schema#comment | "The canonical Wnt/β-catenin pathway is an essential component of multiple developmental processes. To investigate the role of this pathway in the ectoderm during facial morphogenesis, we generated conditional β-catenin mouse mutants using a novel ectoderm-specific Cre recombinase transgenic line. Our results demonstrate that ablating or stabilizing β-catenin in the embryonic ectoderm causes dramatic changes in facial morphology. There are accompanying alterations in the expression of Fgf8 and Shh, key molecules that establish a signaling center critical for facial patterning, the frontonasal ectodermal zone (FEZ). These data indicate that Wnt/β-catenin signaling within the ectoderm is critical for facial development and further suggest that this pathway is an important mechanism for generating the diverse facial shapes of vertebrates during evolution."xsd:string |
| http://purl.uniprot.org/citations/21087601 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ydbio.2010.11.012"xsd:string |
| http://purl.uniprot.org/citations/21087601 | http://purl.uniprot.org/core/author | "Yang H."xsd:string |
| http://purl.uniprot.org/citations/21087601 | http://purl.uniprot.org/core/author | "Williams T."xsd:string |
| http://purl.uniprot.org/citations/21087601 | http://purl.uniprot.org/core/author | "Taketo M.M."xsd:string |
| http://purl.uniprot.org/citations/21087601 | http://purl.uniprot.org/core/author | "Reid B.S."xsd:string |
| http://purl.uniprot.org/citations/21087601 | http://purl.uniprot.org/core/author | "Melvin V.S."xsd:string |
| http://purl.uniprot.org/citations/21087601 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21087601 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/21087601 | http://purl.uniprot.org/core/pages | "261-269"xsd:string |
| http://purl.uniprot.org/citations/21087601 | http://purl.uniprot.org/core/title | "Ectodermal Wnt/beta-catenin signaling shapes the mouse face."xsd:string |
| http://purl.uniprot.org/citations/21087601 | http://purl.uniprot.org/core/volume | "349"xsd:string |
| http://purl.uniprot.org/citations/21087601 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21087601 |
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