| http://purl.uniprot.org/citations/21092756 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21092756 | http://www.w3.org/2000/01/rdf-schema#comment | "Systemic inflammatory response syndrome (SIRS), a serious clinical condition characterized by whole-body inflammation, is particularly threatening for elderly patients, who suffer much higher mortality rates than the young. A major pathological consequence of SIRS is acute lung injury caused by neutrophil-mediated oxidative damage. Previously, we reported an increase in protein tyrosine nitration (a marker of oxidative/nitrosative damage) and a decrease in the antioxidant enzyme extracellular superoxide dismutase (EC-SOD) in the lungs of young mice during endotoxemia-induced SIRS. Here we demonstrate that during endotoxemia, down-regulation of EC-SOD is significantly more profound and prolonged, whereas up-regulation of iNOS is augmented, in aged compared to young mice. Aged mice also showed 2.5-fold higher protein nitration levels, compared to young mice, with particularly strong nitration in the pulmonary vascular endothelium during SIRS. Additionally, by two-dimensional gel electrophoresis, Western blotting, and mass spectrometry, we identified proteins that show increased tyrosine nitration in age- and SIRS-dependent manners; these proteins (profilin-1, transgelin-2, LASP 1, tropomyosin, and myosin) include components of the actin cytoskeleton responsible for maintaining pulmonary vascular permeability. Reduced EC-SOD in combination with increased oxidative/nitrosative damage and altered cytoskeletal protein function due to tyrosine nitration may contribute to augmented lung injury in the aged with SIRS."xsd:string |
| http://purl.uniprot.org/citations/21092756 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.freeradbiomed.2010.11.013"xsd:string |
| http://purl.uniprot.org/citations/21092756 | http://purl.uniprot.org/core/author | "Saito H."xsd:string |
| http://purl.uniprot.org/citations/21092756 | http://purl.uniprot.org/core/author | "Yamamoto S."xsd:string |
| http://purl.uniprot.org/citations/21092756 | http://purl.uniprot.org/core/author | "Ueda J."xsd:string |
| http://purl.uniprot.org/citations/21092756 | http://purl.uniprot.org/core/author | "Evers B.M."xsd:string |
| http://purl.uniprot.org/citations/21092756 | http://purl.uniprot.org/core/author | "Starr M.E."xsd:string |
| http://purl.uniprot.org/citations/21092756 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21092756 | http://purl.uniprot.org/core/name | "Free Radic Biol Med"xsd:string |
| http://purl.uniprot.org/citations/21092756 | http://purl.uniprot.org/core/pages | "371-380"xsd:string |
| http://purl.uniprot.org/citations/21092756 | http://purl.uniprot.org/core/title | "The effects of aging on pulmonary oxidative damage, protein nitration, and extracellular superoxide dismutase down-regulation during systemic inflammation."xsd:string |
| http://purl.uniprot.org/citations/21092756 | http://purl.uniprot.org/core/volume | "50"xsd:string |
| http://purl.uniprot.org/citations/21092756 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21092756 |
| http://purl.uniprot.org/citations/21092756 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21092756 |
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