| http://purl.uniprot.org/citations/21093323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21093323 | http://www.w3.org/2000/01/rdf-schema#comment | "Although canonical Notch signaling regulates multiple hematopoietic lineage decisions including T cell and marginal zone B cell fate specification, the downstream molecular mediators of Notch function are largely unknown. We showed here that conditional inactivation of Hes1, a well-characterized Notch target gene, in adult murine bone marrow (BM) cells severely impaired T cell development without affecting other Notch-dependent hematopoietic lineages such as marginal zone B cells. Competitive mixed BM chimeras, intrathymic transfer experiments, and in vitro culture of BM progenitors on Delta-like-expressing stromal cells further demonstrated that Hes1 is required for T cell lineage commitment, but dispensable for Notch-dependent thymocyte maturation through and beyond the beta selection checkpoint. Furthermore, our data strongly suggest that Hes1 is essential for the development and maintenance of Notch-induced T cell acute lymphoblastic leukemia. Collectively, our studies identify Hes1 as a critical but context-dependent mediator of canonical Notch signaling in the hematopoietic system."xsd:string |
| http://purl.uniprot.org/citations/21093323 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2010.11.014"xsd:string |
| http://purl.uniprot.org/citations/21093323 | http://purl.uniprot.org/core/author | "Koch U."xsd:string |
| http://purl.uniprot.org/citations/21093323 | http://purl.uniprot.org/core/author | "Bruning J.C."xsd:string |
| http://purl.uniprot.org/citations/21093323 | http://purl.uniprot.org/core/author | "Wirth S."xsd:string |
| http://purl.uniprot.org/citations/21093323 | http://purl.uniprot.org/core/author | "Wunderlich F.T."xsd:string |
| http://purl.uniprot.org/citations/21093323 | http://purl.uniprot.org/core/author | "Radtke F."xsd:string |
| http://purl.uniprot.org/citations/21093323 | http://purl.uniprot.org/core/author | "Dubey C."xsd:string |
| http://purl.uniprot.org/citations/21093323 | http://purl.uniprot.org/core/author | "MacDonald H.R."xsd:string |
| http://purl.uniprot.org/citations/21093323 | http://purl.uniprot.org/core/author | "Wendorff A.A."xsd:string |
| http://purl.uniprot.org/citations/21093323 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21093323 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/21093323 | http://purl.uniprot.org/core/pages | "671-684"xsd:string |
| http://purl.uniprot.org/citations/21093323 | http://purl.uniprot.org/core/title | "Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation."xsd:string |
| http://purl.uniprot.org/citations/21093323 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/21093323 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21093323 |
| http://purl.uniprot.org/citations/21093323 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21093323 |
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| http://purl.uniprot.org/uniprot/#_Q3U868-mappedCitation-21093323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21093323 |
| http://purl.uniprot.org/uniprot/#_Q3UZZ2-mappedCitation-21093323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21093323 |
| http://purl.uniprot.org/uniprot/#_Q3TX36-mappedCitation-21093323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21093323 |