| http://purl.uniprot.org/citations/21093551 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21093551 | http://www.w3.org/2000/01/rdf-schema#comment | "In this study we investigated apoptosis and expression of the collagen I gene in newborn rat osteoblasts (OB) by the administration of varying concentrations of fluoride (F). Sodium fluoride (NaF) at concentrations of 0, 0.5, 5, 10, and 20mg/L was administered to cultured OB. The percentage of G(1)/G(0) (Gap 1/Gap 0), S (synthesis), G(2)/M (Gap 2/M, mitosis), and apoptosis rates in OB were analyzed with a Fluorescence-activated Cell Sorter (FACS) by propidium iodine (PI) staining after F treatment of 72 h. Effects of F treatment on COL1A1 and COL1A2 mRNA and collagen I protein levels were determined using quantitative real time RT-PCR (qRT-PCR) and immunofluorescence, respectively. This study demonstrates that there is a pronounced negative effect of long term NaF treatment on OB survival. These negative effects include an inhibition of the transformation from S phase into G(2)/M phase, increased apoptosis, and decreased COL1A1 mRNA, down-regulating the synthesis of COL I protein. The results suggest that COL I protein degradation in OB from F toxicity is due to a depletion of COL1A1 mRNA and not COL1A2."xsd:string |
| http://purl.uniprot.org/citations/21093551 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.toxlet.2010.11.005"xsd:string |
| http://purl.uniprot.org/citations/21093551 | http://purl.uniprot.org/core/author | "Chen Q."xsd:string |
| http://purl.uniprot.org/citations/21093551 | http://purl.uniprot.org/core/author | "Li J."xsd:string |
| http://purl.uniprot.org/citations/21093551 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/21093551 | http://purl.uniprot.org/core/author | "Yan X."xsd:string |
| http://purl.uniprot.org/citations/21093551 | http://purl.uniprot.org/core/author | "Han T."xsd:string |
| http://purl.uniprot.org/citations/21093551 | http://purl.uniprot.org/core/author | "Morrison A."xsd:string |
| http://purl.uniprot.org/citations/21093551 | http://purl.uniprot.org/core/author | "Yan X.'"xsd:string |
| http://purl.uniprot.org/citations/21093551 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21093551 | http://purl.uniprot.org/core/name | "Toxicol Lett"xsd:string |
| http://purl.uniprot.org/citations/21093551 | http://purl.uniprot.org/core/pages | "133-138"xsd:string |
| http://purl.uniprot.org/citations/21093551 | http://purl.uniprot.org/core/title | "Fluoride induces apoptosis and alters collagen I expression in rat osteoblasts."xsd:string |
| http://purl.uniprot.org/citations/21093551 | http://purl.uniprot.org/core/volume | "200"xsd:string |
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