| http://purl.uniprot.org/citations/2109694 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2109694 | http://www.w3.org/2000/01/rdf-schema#comment | "G proteins couple receptors for extracellular signals to several intracellular effector systems and play a key role in signalling transduction mechanisms. In particulate preparations of Drosophila melanogaster heads, only one substrate for pertussis toxin at 39-40 kd was detected. This substrate, which showed only one isoform when analysed by isoelectric focusing, was recognized by immunoblotting and immunoprecipitation techniques using a polyclonal antibody against the alpha subunit of the Go protein purified from bovine brain and can be thus considered as a Go-like protein. Antibodies obtained against a carboxy-terminal sequence of the alpha subunit of Go (but not of Gi1 or Gi2) and against an internal sequence shared by all the alpha subunits, were also able to cross-react with the alpha subunit of this protein in insects. We have also studied the Go-like protein in several D.melanogaster mutants, primarily in memory and learning mutants. In these mutants there was a sex-dependent enhancement in pertussis toxin-catalysed ADP-ribosylation with respect to the wild-type. This increase could be attributed in part to an increase in the alpha subunit of the Go-like protein, as revealed by immunoblotting with anti-Go alpha polyclonal antibody. This report constitutes the first evidence for the participation of a Go protein in learning and memory."xsd:string |
| http://purl.uniprot.org/citations/2109694 | http://purl.org/dc/terms/identifier | "doi:10.1002/j.1460-2075.1990.tb08261.x"xsd:string |
| http://purl.uniprot.org/citations/2109694 | http://purl.uniprot.org/core/author | "Bockaert J."xsd:string |
| http://purl.uniprot.org/citations/2109694 | http://purl.uniprot.org/core/author | "Homburger V."xsd:string |
| http://purl.uniprot.org/citations/2109694 | http://purl.uniprot.org/core/author | "Pantaloni C."xsd:string |
| http://purl.uniprot.org/citations/2109694 | http://purl.uniprot.org/core/author | "Guillen A."xsd:string |
| http://purl.uniprot.org/citations/2109694 | http://purl.uniprot.org/core/author | "Jallon J.M."xsd:string |
| http://purl.uniprot.org/citations/2109694 | http://purl.uniprot.org/core/author | "Fehrentz J.A."xsd:string |
| http://purl.uniprot.org/citations/2109694 | http://purl.uniprot.org/core/date | "1990"xsd:gYear |
| http://purl.uniprot.org/citations/2109694 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/2109694 | http://purl.uniprot.org/core/pages | "1449-1455"xsd:string |
| http://purl.uniprot.org/citations/2109694 | http://purl.uniprot.org/core/title | "A Go-like protein in Drosophila melanogaster and its expression in memory mutants."xsd:string |
| http://purl.uniprot.org/citations/2109694 | http://purl.uniprot.org/core/volume | "9"xsd:string |
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