| http://purl.uniprot.org/citations/21097671 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21097671 | http://www.w3.org/2000/01/rdf-schema#comment | "Clinical observations and laboratory evidence link bone marrow failure in myelodysplastic syndrome (MDS) to a T cell-mediated immune process that is responsive to immunosuppressive treatment (IST) in some patients. Previously, we showed that trisomy 8 MDS patients had clonally expanded CD8(+) T-cell populations that recognized aneuploid hematopoietic progenitor cells (HPC). Furthermore, microarray analyses showed that Wilms tumor 1 (WT1) gene was overexpressed by trisomy 8 hematopoietic progenitor (CD34(+)) cells compared with CD34(+) cells from healthy donors. Here, we show that WT1 mRNA expression is up-regulated in the bone marrow mononuclear cells of MDS patients with trisomy 8 relative to healthy controls and non-trisomy 8 MDS; WT1 protein levels were also significantly elevated. In addition, using a combination of physical and functional assays to detect the presence and reactivity of specific T cells, respectively, we demonstrate that IST-responsive MDS patients exhibit significant CD4(+) and CD8(+) T-cell responses directed against WT1. Finally, WT1-specific CD8(+) T cells were present within expanded T-cell receptor Vβ subfamilies and inhibited hematopoiesis when added to autologous patient bone marrow cells in culture. Thus, our results suggest that WT1 is one of the antigens that triggers T cell-mediated myelosuppression in MDS."xsd:string |
| http://purl.uniprot.org/citations/21097671 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2010-04-277921"xsd:string |
| http://purl.uniprot.org/citations/21097671 | http://purl.uniprot.org/core/author | "Barrett A.J."xsd:string |
| http://purl.uniprot.org/citations/21097671 | http://purl.uniprot.org/core/author | "Wu C."xsd:string |
| http://purl.uniprot.org/citations/21097671 | http://purl.uniprot.org/core/author | "Young N.S."xsd:string |
| http://purl.uniprot.org/citations/21097671 | http://purl.uniprot.org/core/author | "Price D.A."xsd:string |
| http://purl.uniprot.org/citations/21097671 | http://purl.uniprot.org/core/author | "Gostick E."xsd:string |
| http://purl.uniprot.org/citations/21097671 | http://purl.uniprot.org/core/author | "Melenhorst J.J."xsd:string |
| http://purl.uniprot.org/citations/21097671 | http://purl.uniprot.org/core/author | "Scheinberg P."xsd:string |
| http://purl.uniprot.org/citations/21097671 | http://purl.uniprot.org/core/author | "Yong A."xsd:string |
| http://purl.uniprot.org/citations/21097671 | http://purl.uniprot.org/core/author | "Visconte V."xsd:string |
| http://purl.uniprot.org/citations/21097671 | http://purl.uniprot.org/core/author | "Douek D.C."xsd:string |
| http://purl.uniprot.org/citations/21097671 | http://purl.uniprot.org/core/author | "Brenchley J.M."xsd:string |
| http://purl.uniprot.org/citations/21097671 | http://purl.uniprot.org/core/author | "Pfannes L."xsd:string |
| http://purl.uniprot.org/citations/21097671 | http://purl.uniprot.org/core/author | "Sloand E.M."xsd:string |
| http://purl.uniprot.org/citations/21097671 | http://purl.uniprot.org/core/author | "Olnes M.J."xsd:string |
| http://purl.uniprot.org/citations/21097671 | http://purl.uniprot.org/core/author | "Tucker Z.C."xsd:string |
| http://purl.uniprot.org/citations/21097671 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21097671 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/21097671 | http://purl.uniprot.org/core/pages | "2691-2699"xsd:string |
| http://purl.uniprot.org/citations/21097671 | http://purl.uniprot.org/core/title | "T-cell immune responses to Wilms tumor 1 protein in myelodysplasia responsive to immunosuppressive therapy."xsd:string |
| http://purl.uniprot.org/citations/21097671 | http://purl.uniprot.org/core/volume | "117"xsd:string |
| http://purl.uniprot.org/citations/21097671 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21097671 |
| http://purl.uniprot.org/citations/21097671 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21097671 |