| http://purl.uniprot.org/citations/21098273 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21098273 | http://www.w3.org/2000/01/rdf-schema#comment | "The switch between black and yellow pigment is mediated by the interaction between Melanocortin receptor 1 (Mc1r) and its antagonist Agouti, but the genetic and developmental mechanisms that modify this interaction to obtain different coat color in distinct environments are poorly understood. Here, the role of Wnt/β-catenin signaling in the regulation of pigment-type switching was studied. Loss and gain of function of β-catenin in the dermal papilla (DP) of the hair follicle results in yellow and black animals, respectively. β-Catenin activity in the DP suppresses Agouti expression and activates Corin, a negative regulator of Agouti activity. In addition, β-catenin activity in the DP regulates melanocyte activity by a mechanism that is independent of both Agouti and Corin. The coordinate and inverse regulation of Agouti and Corin renders pelage pigmentation sensitive to changes in β-catenin activity in the DP that do not alter pelage structure. As a result, the signals that specify two biologically distinct quantitative traits are partially uncoupled despite their common regulation by the β-catenin pathway in the same cells."xsd:string |
| http://purl.uniprot.org/citations/21098273 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1007326107"xsd:string |
| http://purl.uniprot.org/citations/21098273 | http://purl.uniprot.org/core/author | "Taketo M.M."xsd:string |
| http://purl.uniprot.org/citations/21098273 | http://purl.uniprot.org/core/author | "Morgan B.A."xsd:string |
| http://purl.uniprot.org/citations/21098273 | http://purl.uniprot.org/core/author | "Lindon C."xsd:string |
| http://purl.uniprot.org/citations/21098273 | http://purl.uniprot.org/core/author | "Wu E."xsd:string |
| http://purl.uniprot.org/citations/21098273 | http://purl.uniprot.org/core/author | "Enshell-Seijffers D."xsd:string |
| http://purl.uniprot.org/citations/21098273 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21098273 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/21098273 | http://purl.uniprot.org/core/pages | "21564-21569"xsd:string |
| http://purl.uniprot.org/citations/21098273 | http://purl.uniprot.org/core/title | "Beta-catenin activity in the dermal papilla of the hair follicle regulates pigment-type switching."xsd:string |
| http://purl.uniprot.org/citations/21098273 | http://purl.uniprot.org/core/volume | "107"xsd:string |
| http://purl.uniprot.org/citations/21098273 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21098273 |
| http://purl.uniprot.org/citations/21098273 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21098273 |
| http://purl.uniprot.org/uniprot/#_D3Z7S6-mappedCitation-21098273 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21098273 |
| http://purl.uniprot.org/uniprot/#_D3Z5Q1-mappedCitation-21098273 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21098273 |
| http://purl.uniprot.org/uniprot/#_E9Q6A9-mappedCitation-21098273 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21098273 |
| http://purl.uniprot.org/uniprot/#_F7CRC6-mappedCitation-21098273 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21098273 |
| http://purl.uniprot.org/uniprot/#_D3YUH4-mappedCitation-21098273 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21098273 |
| http://purl.uniprot.org/uniprot/#_B7ZNH6-mappedCitation-21098273 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21098273 |
| http://purl.uniprot.org/uniprot/#_F7BAC9-mappedCitation-21098273 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21098273 |
| http://purl.uniprot.org/uniprot/#_E9PW26-mappedCitation-21098273 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21098273 |
| http://purl.uniprot.org/uniprot/#_H3BLR7-mappedCitation-21098273 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21098273 |
| http://purl.uniprot.org/uniprot/#_F6QZ47-mappedCitation-21098273 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21098273 |