| http://purl.uniprot.org/citations/21098667 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21098667 | http://www.w3.org/2000/01/rdf-schema#comment | "The Mediator complex forms the bridge between transcriptional activators and the RNA polymerase II. Med1 (also known as PBP or TRAP220) is a key component of Mediator that interacts with nuclear hormone receptors and GATA transcription factors. Here, we show dynamic recruitment of GATA-1, TFIIB, Mediator, and RNA polymerase II to the β-globin locus in induced mouse erythroid leukemia cells and in an erythropoietin-inducible hematopoietic progenitor cell line. Using Med1 conditional knockout mice, we demonstrate a specific block in erythroid development but not in myeloid or lymphoid development, highlighted by the complete absence of β-globin gene expression. Thus, Mediator subunit Med1 plays a pivotal role in erythroid development and in β-globin gene activation."xsd:string |
| http://purl.uniprot.org/citations/21098667 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1005794107"xsd:string |
| http://purl.uniprot.org/citations/21098667 | http://purl.uniprot.org/core/author | "Yue X."xsd:string |
| http://purl.uniprot.org/citations/21098667 | http://purl.uniprot.org/core/author | "Reddy J.K."xsd:string |
| http://purl.uniprot.org/citations/21098667 | http://purl.uniprot.org/core/author | "Stumpf M."xsd:string |
| http://purl.uniprot.org/citations/21098667 | http://purl.uniprot.org/core/author | "Schmitz S."xsd:string |
| http://purl.uniprot.org/citations/21098667 | http://purl.uniprot.org/core/author | "Borggrefe T."xsd:string |
| http://purl.uniprot.org/citations/21098667 | http://purl.uniprot.org/core/author | "Luche H."xsd:string |
| http://purl.uniprot.org/citations/21098667 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21098667 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/21098667 | http://purl.uniprot.org/core/pages | "21541-21546"xsd:string |
| http://purl.uniprot.org/citations/21098667 | http://purl.uniprot.org/core/title | "Specific erythroid-lineage defect in mice conditionally deficient for Mediator subunit Med1."xsd:string |
| http://purl.uniprot.org/citations/21098667 | http://purl.uniprot.org/core/volume | "107"xsd:string |
| http://purl.uniprot.org/citations/21098667 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21098667 |
| http://purl.uniprot.org/citations/21098667 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21098667 |
| http://purl.uniprot.org/uniprot/Q925J9#attribution-E4C8727684B289CE033A09C2186891FC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21098667 |
| http://purl.uniprot.org/uniprot/#_B1AQH6-mappedCitation-21098667 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21098667 |
| http://purl.uniprot.org/uniprot/#_Q925J9-mappedCitation-21098667 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21098667 |
| http://purl.uniprot.org/uniprot/Q925J9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21098667 |
| http://purl.uniprot.org/uniprot/B1AQH6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/21098667 |