| http://purl.uniprot.org/citations/21099262 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21099262 | http://www.w3.org/2000/01/rdf-schema#comment | "Pancreatic beta-cells show oscillations in membrane potential (Vm), the cytosolic Ca (2+) concentration ([Ca (2+) ]c) and finally insulin secretion. It is well accepted that the initiation of a burst phase with action potentials is mediated by voltage-dependent Ca (2+) (and Na (+) ) channels. The mechanism triggering the onset of interburst phases is less clear. The exact nature of the K (+) channels that hyperpolarize Vm to maintain the rhythmic activity is unknown. In 1999 Göpel and co-workers (1) described a current termed Kslow and claimed that this current terminates the burst phases. KATP current is a part of the Kslow current. We could show that the Ca (2+) -dependent K (+) current through K (+) channels of intermediate conductance (SK4, KCa3.1 or IK1) also contributes to the Kslow current. We suggest that the Kslow current is composed of two currents through metabolism-regulated K (+) channels, KATP (regulated by ATP) and SK4 (regulated by Ca (2+) ). We further propose that the SK4 component of the Kslow current can trigger oscillations in mice without functioning KATP channels."xsd:string |
| http://purl.uniprot.org/citations/21099262 | http://purl.org/dc/terms/identifier | "doi:10.4161/isl.1.2.9056"xsd:string |
| http://purl.uniprot.org/citations/21099262 | http://purl.uniprot.org/core/author | "Drews G."xsd:string |
| http://purl.uniprot.org/citations/21099262 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/21099262 | http://purl.uniprot.org/core/name | "Islets"xsd:string |
| http://purl.uniprot.org/citations/21099262 | http://purl.uniprot.org/core/pages | "148-150"xsd:string |
| http://purl.uniprot.org/citations/21099262 | http://purl.uniprot.org/core/title | "Physiological significance of SK4 channels in pancreatic beta-cell oscillations."xsd:string |
| http://purl.uniprot.org/citations/21099262 | http://purl.uniprot.org/core/volume | "1"xsd:string |
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