| http://purl.uniprot.org/citations/21102435 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21102435 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21102435 | http://www.w3.org/2000/01/rdf-schema#comment | "The poly(ADP-ribose) polymerases (PARPs) participate in many biological and pathological processes. Here we report that the PARP-13 shorter isoform (ZAPS), rather than the full-length protein (ZAP), was selectively induced by 5'-triphosphate-modified RNA (3pRNA) and functioned as a potent stimulator of interferon responses in human cells mediated by the RNA helicase RIG-I. ZAPS associated with RIG-I to promote the oligomerization and ATPase activity of RIG-I, which led to robust activation of IRF3 and NF-κB transcription factors. Disruption of the gene encoding ZAPS resulted in impaired induction of interferon-α (IFN-α), IFN-β and other cytokines after viral infection. These results indicate that ZAPS is a key regulator of RIG-I signaling during the innate antiviral immune response, which suggests its possible use as a therapeutic target for viral control."xsd:string |
| http://purl.uniprot.org/citations/21102435 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1963"xsd:string |
| http://purl.uniprot.org/citations/21102435 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1963"xsd:string |
| http://purl.uniprot.org/citations/21102435 | http://purl.uniprot.org/core/author | "Goto S."xsd:string |
| http://purl.uniprot.org/citations/21102435 | http://purl.uniprot.org/core/author | "Goto S."xsd:string |
| http://purl.uniprot.org/citations/21102435 | http://purl.uniprot.org/core/author | "Miyazaki T."xsd:string |
| http://purl.uniprot.org/citations/21102435 | http://purl.uniprot.org/core/author | "Miyazaki T."xsd:string |
| http://purl.uniprot.org/citations/21102435 | http://purl.uniprot.org/core/author | "Sato M."xsd:string |
| http://purl.uniprot.org/citations/21102435 | http://purl.uniprot.org/core/author | "Sato M."xsd:string |
| http://purl.uniprot.org/citations/21102435 | http://purl.uniprot.org/core/author | "Ohba Y."xsd:string |
| http://purl.uniprot.org/citations/21102435 | http://purl.uniprot.org/core/author | "Ohba Y."xsd:string |
| http://purl.uniprot.org/citations/21102435 | http://purl.uniprot.org/core/author | "Yamada T."xsd:string |
| http://purl.uniprot.org/citations/21102435 | http://purl.uniprot.org/core/author | "Yamada T."xsd:string |
| http://purl.uniprot.org/citations/21102435 | http://purl.uniprot.org/core/author | "Imamura M."xsd:string |
| http://purl.uniprot.org/citations/21102435 | http://purl.uniprot.org/core/author | "Imamura M."xsd:string |
| http://purl.uniprot.org/citations/21102435 | http://purl.uniprot.org/core/author | "Tanaka J."xsd:string |
| http://purl.uniprot.org/citations/21102435 | http://purl.uniprot.org/core/author | "Tanaka J."xsd:string |
| http://purl.uniprot.org/citations/21102435 | http://purl.uniprot.org/core/author | "Hayakawa S."xsd:string |
| http://purl.uniprot.org/citations/21102435 | http://purl.uniprot.org/core/author | "Hayakawa S."xsd:string |
| http://purl.uniprot.org/citations/21102435 | http://purl.uniprot.org/core/author | "Fujikura D."xsd:string |
| http://purl.uniprot.org/citations/21102435 | http://purl.uniprot.org/core/author | "Fujikura D."xsd:string |
| http://purl.uniprot.org/citations/21102435 | http://purl.uniprot.org/core/author | "Mizutani T."xsd:string |
| http://purl.uniprot.org/citations/21102435 | http://purl.uniprot.org/core/author | "Mizutani T."xsd:string |