| http://purl.uniprot.org/citations/21102635 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21102635 | http://www.w3.org/2000/01/rdf-schema#comment | "There is now considerable and increasing evidence for a causal role for aberrant activity of the Ras superfamily of small GTPases in human cancers. These GTPases function as GDP-GTP-regulated binary switches that control many fundamental cellular processes. A common mechanism of GTPase deregulation in cancer is the deregulated expression and/or activity of their regulatory proteins, guanine nucleotide exchange factors (GEFs) that promote formation of the active GTP-bound state and GTPase-activating proteins (GAPs) that return the GTPase to its GDP-bound inactive state. In this Review, we assess the association of GEFs and GAPs with cancer and their druggability for cancer therapeutics."xsd:string |
| http://purl.uniprot.org/citations/21102635 | http://purl.org/dc/terms/identifier | "doi:10.1038/nrc2960"xsd:string |
| http://purl.uniprot.org/citations/21102635 | http://purl.uniprot.org/core/author | "Cherfils J."xsd:string |
| http://purl.uniprot.org/citations/21102635 | http://purl.uniprot.org/core/author | "Der C.J."xsd:string |
| http://purl.uniprot.org/citations/21102635 | http://purl.uniprot.org/core/author | "Rossman K.L."xsd:string |
| http://purl.uniprot.org/citations/21102635 | http://purl.uniprot.org/core/author | "Vigil D."xsd:string |
| http://purl.uniprot.org/citations/21102635 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21102635 | http://purl.uniprot.org/core/name | "Nat Rev Cancer"xsd:string |
| http://purl.uniprot.org/citations/21102635 | http://purl.uniprot.org/core/pages | "842-857"xsd:string |
| http://purl.uniprot.org/citations/21102635 | http://purl.uniprot.org/core/title | "Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?"xsd:string |
| http://purl.uniprot.org/citations/21102635 | http://purl.uniprot.org/core/volume | "10"xsd:string |
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