| http://purl.uniprot.org/citations/21107423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21107423 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21107423 | http://www.w3.org/2000/01/rdf-schema#comment | "Members of the Wiskott-Aldrich syndrome protein (WASP) family control cytoskeletal dynamics by promoting actin filament nucleation with the Arp2/3 complex. The WASP relative WAVE regulates lamellipodia formation within a 400-kilodalton, hetero-pentameric WAVE regulatory complex (WRC). The WRC is inactive towards the Arp2/3 complex, but can be stimulated by the Rac GTPase, kinases and phosphatidylinositols. Here we report the 2.3-ångstrom crystal structure of the WRC and complementary mechanistic analyses. The structure shows that the activity-bearing VCA motif of WAVE is sequestered by a combination of intramolecular and intermolecular contacts within the WRC. Rac and kinases appear to destabilize a WRC element that is necessary for VCA sequestration, suggesting the way in which these signals stimulate WRC activity towards the Arp2/3 complex. The spatial proximity of the Rac binding site and the large basic surface of the WRC suggests how the GTPase and phospholipids could cooperatively recruit the complex to membranes."xsd:string |
| http://purl.uniprot.org/citations/21107423 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature09623"xsd:string |
| http://purl.uniprot.org/citations/21107423 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature09623"xsd:string |
| http://purl.uniprot.org/citations/21107423 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/21107423 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/21107423 | http://purl.uniprot.org/core/author | "Borek D."xsd:string |
| http://purl.uniprot.org/citations/21107423 | http://purl.uniprot.org/core/author | "Borek D."xsd:string |
| http://purl.uniprot.org/citations/21107423 | http://purl.uniprot.org/core/author | "Metlagel Z."xsd:string |
| http://purl.uniprot.org/citations/21107423 | http://purl.uniprot.org/core/author | "Metlagel Z."xsd:string |
| http://purl.uniprot.org/citations/21107423 | http://purl.uniprot.org/core/author | "Otwinowski Z."xsd:string |
| http://purl.uniprot.org/citations/21107423 | http://purl.uniprot.org/core/author | "Otwinowski Z."xsd:string |
| http://purl.uniprot.org/citations/21107423 | http://purl.uniprot.org/core/author | "Billadeau D.D."xsd:string |
| http://purl.uniprot.org/citations/21107423 | http://purl.uniprot.org/core/author | "Billadeau D.D."xsd:string |
| http://purl.uniprot.org/citations/21107423 | http://purl.uniprot.org/core/author | "Gomez T.S."xsd:string |
| http://purl.uniprot.org/citations/21107423 | http://purl.uniprot.org/core/author | "Gomez T.S."xsd:string |
| http://purl.uniprot.org/citations/21107423 | http://purl.uniprot.org/core/author | "Ismail A.M."xsd:string |
| http://purl.uniprot.org/citations/21107423 | http://purl.uniprot.org/core/author | "Ismail A.M."xsd:string |
| http://purl.uniprot.org/citations/21107423 | http://purl.uniprot.org/core/author | "Padrick S.B."xsd:string |
| http://purl.uniprot.org/citations/21107423 | http://purl.uniprot.org/core/author | "Padrick S.B."xsd:string |
| http://purl.uniprot.org/citations/21107423 | http://purl.uniprot.org/core/author | "Rosen M.K."xsd:string |
| http://purl.uniprot.org/citations/21107423 | http://purl.uniprot.org/core/author | "Rosen M.K."xsd:string |
| http://purl.uniprot.org/citations/21107423 | http://purl.uniprot.org/core/author | "Umetani J."xsd:string |
| http://purl.uniprot.org/citations/21107423 | http://purl.uniprot.org/core/author | "Umetani J."xsd:string |