| http://purl.uniprot.org/citations/21108476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21108476 | http://www.w3.org/2000/01/rdf-schema#comment | "Death domain-associated protein (Daxx) is a multifunctional protein that modulates both cell death and transcription. Several recent studies have indicated that Daxx is a mediator of lymphocyte death and/or growth suppression, although the detailed mechanism is unclear. Previously, we reported that Daxx suppresses IL-6 family cytokine-induced gene expression by interacting with STAT3. STAT3 is important for the growth and survival of lymphocytes; therefore, we here examined the role of Daxx in the gp130/STAT3-dependent cell growth/survival signals. We found that Daxx suppresses the gp130/STAT3-dependent cell growth and that Daxx endogenously interacts with STAT3 and inhibits the DNA-binding activity of STAT3. Moreover, small-interfering RNA-mediated knockdown of Daxx enhanced the expression of STAT3-target genes and accelerated the STAT3-mediated cell cycle progression. In addition, knockdown of Daxx-attenuated lactate dehydrogenase leakage from cells, indicating that Daxx positively regulates cell death during gp130/STAT3-mediated cell proliferation. Notably, Daxx specifically suppressed the levels of Bcl2 mRNA and protein, even in cytokine-unstimulated cells, indicating that Daxx regulates Bcl2 expression independently of activated STAT3. These results suggest that Daxx suppresses gp130-mediated cell growth and survival by two independent mechanisms: inhibition of STAT3-induced transcription and down-regulation of Bcl2 expression."xsd:string |
| http://purl.uniprot.org/citations/21108476 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201040688"xsd:string |
| http://purl.uniprot.org/citations/21108476 | http://purl.uniprot.org/core/author | "Kuroda M."xsd:string |
| http://purl.uniprot.org/citations/21108476 | http://purl.uniprot.org/core/author | "Matsuda T."xsd:string |
| http://purl.uniprot.org/citations/21108476 | http://purl.uniprot.org/core/author | "Oritani K."xsd:string |
| http://purl.uniprot.org/citations/21108476 | http://purl.uniprot.org/core/author | "Nanbo A."xsd:string |
| http://purl.uniprot.org/citations/21108476 | http://purl.uniprot.org/core/author | "Muromoto R."xsd:string |
| http://purl.uniprot.org/citations/21108476 | http://purl.uniprot.org/core/author | "Sekine Y."xsd:string |
| http://purl.uniprot.org/citations/21108476 | http://purl.uniprot.org/core/author | "Shimoda K."xsd:string |
| http://purl.uniprot.org/citations/21108476 | http://purl.uniprot.org/core/author | "Togi S."xsd:string |
| http://purl.uniprot.org/citations/21108476 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21108476 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/21108476 | http://purl.uniprot.org/core/pages | "3570-3580"xsd:string |
| http://purl.uniprot.org/citations/21108476 | http://purl.uniprot.org/core/title | "Functional involvement of Daxx in gp130-mediated cell growth and survival in BaF3 cells."xsd:string |
| http://purl.uniprot.org/citations/21108476 | http://purl.uniprot.org/core/volume | "40"xsd:string |
| http://purl.uniprot.org/citations/21108476 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/21108476 |
| http://purl.uniprot.org/citations/21108476 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/21108476 |
| http://purl.uniprot.org/uniprot/#_A0A068BEP5-mappedCitation-21108476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21108476 |
| http://purl.uniprot.org/uniprot/#_A1A558-mappedCitation-21108476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21108476 |
| http://purl.uniprot.org/uniprot/#_G3UWI4-mappedCitation-21108476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21108476 |
| http://purl.uniprot.org/uniprot/#_G3UWJ9-mappedCitation-21108476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21108476 |
| http://purl.uniprot.org/uniprot/#_G3UYN8-mappedCitation-21108476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21108476 |
| http://purl.uniprot.org/uniprot/#_G3UX50-mappedCitation-21108476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21108476 |
| http://purl.uniprot.org/uniprot/#_Q3U0Z3-mappedCitation-21108476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/21108476 |