| http://purl.uniprot.org/citations/21118991 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21118991 | http://www.w3.org/2000/01/rdf-schema#comment | "Wnt/β-catenin signaling plays a central role in development and is also involved in a diverse array of diseases. β-Catenin activity is tightly regulated via a multiprotein complex that includes the kinase glycogen synthase kinase-3β (GSK-3β). GSK-3β phosphorylates β-catenin, marking it for ubiquitination and degradation via the proteasome. Thus in regulation of the Wnt pathway, the ubiquitin system is known to be involved mostly in mediating the turnover of β-catenin, resulting in reduced Wnt signaling levels. Here we report that an arm of the ubiquitin system increases β-catenin protein levels. We show that GSK-3β directly interacts with the E3 ubiquitin ligase identified by differential display (EDD) that also binds β-catenin. Expression of EDD leads to enhanced nuclear accumulation of both GSK-3β and β-catenin and results in up-regulation of β-catenin expression levels and activity. Importantly, EDD ubiquitinates β-catenin through Lys29- or Lys11-linked ubiquitin chains, leading to enhanced stability of β-catenin. Our results demonstrate a role for the ubiquitin system in up-regulation of the Wnt signaling pathway, suggesting that EDD could function as a colorectal oncogene."xsd:string |
| http://purl.uniprot.org/citations/21118991 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e10-05-0440"xsd:string |
| http://purl.uniprot.org/citations/21118991 | http://purl.uniprot.org/core/author | "Rosin-Arbesfeld R."xsd:string |
| http://purl.uniprot.org/citations/21118991 | http://purl.uniprot.org/core/author | "Caspi M."xsd:string |
| http://purl.uniprot.org/citations/21118991 | http://purl.uniprot.org/core/author | "Zilberberg A."xsd:string |
| http://purl.uniprot.org/citations/21118991 | http://purl.uniprot.org/core/author | "Hay-Koren A."xsd:string |
| http://purl.uniprot.org/citations/21118991 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/21118991 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/21118991 | http://purl.uniprot.org/core/pages | "399-411"xsd:string |
| http://purl.uniprot.org/citations/21118991 | http://purl.uniprot.org/core/title | "The EDD E3 ubiquitin ligase ubiquitinates and up-regulates beta-catenin."xsd:string |
| http://purl.uniprot.org/citations/21118991 | http://purl.uniprot.org/core/volume | "22"xsd:string |
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| http://purl.uniprot.org/uniprot/O95071#attribution-794F7699BE976D057D94F750C981C3E1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/21118991 |
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