| http://purl.uniprot.org/citations/21119626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/21119626 | http://www.w3.org/2000/01/rdf-schema#comment | "Protein-metabolite networks are central to biological systems, but are incompletely understood. Here, we report a screen to catalog protein-lipid interactions in yeast. We used arrays of 56 metabolites to measure lipid-binding fingerprints of 172 proteins, including 91 with predicted lipid-binding domains. We identified 530 protein-lipid associations, the majority of which are novel. To show the data set's biological value, we studied further several novel interactions with sphingolipids, a class of conserved bioactive lipids with an elusive mode of action. Integration of live-cell imaging suggests new cellular targets for these molecules, including several with pleckstrin homology (PH) domains. Validated interactions with Slm1, a regulator of actin polarization, show that PH domains can have unexpected lipid-binding specificities and can act as coincidence sensors for both phosphatidylinositol phosphates and phosphorylated sphingolipids."xsd:string |
| http://purl.uniprot.org/citations/21119626 | http://purl.org/dc/terms/identifier | "doi:10.1038/msb.2010.87"xsd:string |
| http://purl.uniprot.org/citations/21119626 | http://purl.uniprot.org/core/author | "Bork P."xsd:string |
| http://purl.uniprot.org/citations/21119626 | http://purl.uniprot.org/core/author | "Kuhn M."xsd:string |
| http://purl.uniprot.org/citations/21119626 | http://purl.uniprot.org/core/author | "Jensen L.J."xsd:string |
| http://purl.uniprot.org/citations/21119626 | http://purl.uniprot.org/core/author | "Maeda K."xsd:string |
| http://purl.uniprot.org/citations/21119626 | http://purl.uniprot.org/core/author | "Muller C.W."xsd:string |
| http://purl.uniprot.org/citations/21119626 | http://purl.uniprot.org/core/author | "Russell R.B."xsd:string |
| http://purl.uniprot.org/citations/21119626 | http://purl.uniprot.org/core/author | "Rybin V."xsd:string |
| http://purl.uniprot.org/citations/21119626 | http://purl.uniprot.org/core/author | "Beltran-Alvarez P."xsd:string |
| http://purl.uniprot.org/citations/21119626 | http://purl.uniprot.org/core/author | "Gallego O."xsd:string |
| http://purl.uniprot.org/citations/21119626 | http://purl.uniprot.org/core/author | "Gavin A.C."xsd:string |
| http://purl.uniprot.org/citations/21119626 | http://purl.uniprot.org/core/author | "Kaksonen M."xsd:string |
| http://purl.uniprot.org/citations/21119626 | http://purl.uniprot.org/core/author | "Fernandez-Tornero C."xsd:string |
| http://purl.uniprot.org/citations/21119626 | http://purl.uniprot.org/core/author | "Betts M.J."xsd:string |
| http://purl.uniprot.org/citations/21119626 | http://purl.uniprot.org/core/author | "Aguilar-Gurrieri C."xsd:string |
| http://purl.uniprot.org/citations/21119626 | http://purl.uniprot.org/core/author | "Gvozdenovic-Jeremic J."xsd:string |
| http://purl.uniprot.org/citations/21119626 | http://purl.uniprot.org/core/author | "Bonn S."xsd:string |
| http://purl.uniprot.org/citations/21119626 | http://purl.uniprot.org/core/author | "Trott J."xsd:string |
| http://purl.uniprot.org/citations/21119626 | http://purl.uniprot.org/core/author | "Matetzki C."xsd:string |
| http://purl.uniprot.org/citations/21119626 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/21119626 | http://purl.uniprot.org/core/name | "Mol Syst Biol"xsd:string |
| http://purl.uniprot.org/citations/21119626 | http://purl.uniprot.org/core/pages | "430"xsd:string |
| http://purl.uniprot.org/citations/21119626 | http://purl.uniprot.org/core/title | "A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae."xsd:string |